• 2024
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PubMedにリンクしています

2024 

• Muromachi N, Ishida J, Noguchi K, Akiyama T, Maruhashi S, Motomura K, Usui J, Yamagata K, Fukamizu A.
  Cardiorenal damages in mice at early phase after intervention induced by angiotensin II, nephrectomy, and salt intake.
  Exp. Anim. 31, 102963 (2024) doi: 10.1538/expanim.23-0071

2023

• Nabekura T, Deborah EA, Tahara S, Arai Y, Love PE, Kako Koichir , Fukamizu Akiyosh , Muratani Masafum , Shibuya Akira.
  Themis2 regulates natural killer cell memory function and and formation.
  Nat. Commun, 14 (1): 7200 (2023) doi: 10.1038/s41467-023-42578-8.
  
  
• Kim JD, Kwon C, Nakamura K, Muromachi N, Mori H, Muroi SI, Yamada Y, Saito H, Nakagawa Y, Fukamizu A
  Increased angiotensin II coupled with decreased Adra1a expression enhances cardiac hypertrophy in pregnancy-associated hypertensive mice.
  J. Biol. Chem. 31, 102963 (2023) doi: 10.1016/j.jbc.2023.102964

• Yamada D, Kojima Y, Hosoya A, Suzuki M, Watabe T, Inoue T, Tsugawa N, Asakawa T, Yonemoto Y,
  Onizawa M, Nemoto Y, Oshima S, Shimonaka M, Kuba K, Ishida J, Fukamizu A, Penninger JM, Watanabe M, Okamoto R, Nagaishi T
  Apelin expression is downregulated in T cells in a murine model of chronic colitis.
  Biochem. Biophys Res. Commun. 647, 72-79 (2023) doi: 10.1016/j.bbrc.2023.01.068

• Kasai F, Kako K, Maruhashi S, Uetake T, Yao Y, Daitoku H and Fukamizu A
  γ-enolase (ENO2) is methylated at the Nτ position of His-190 among enolase isozymes.
  J. Biochem. 174, 279-289 (2023) doi: 10.1093/jb/mvad042 プレスリリースはこちら

• Hayashi T, Daitoku H, Uetake T, Kako K and Fukamizu A
  Histidine Nτ-methylation identified as a new posttranslational modification in histone H2A at His-82 and H3 at His-39
  J. Biol. Chem. 299, 105131 (2023) doi: 10.1016/j.jbc.2023.105131 プレスリリースはこちら

2022

• Ozawa K, Shinkai Y, Kako K, Fukamizu A, Doi M 
  The molecular and neural regulation of ultraviolet light phototaxis and its food-associated learning behavioral plasticity in C. elegans.
  Neurosci. lett. 770, 136384. (2022) doi: 10.1016/j.neulet.2021.136384

• Tokudome T, Otani K, Mao Y, Jensen LJ, Arai Y, Miyazaki T, Sonobe T, Pearson JT, Osaki T, Minamino N, Ishida J, Fukamizu A, Kawakami H, Onozuka D, Nishimura K, Miyazato M, Nishimura H
  Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide.
  Hypertension 79, 1409-1422. (2022) doi: 10.1161/HYPERTENSIONAHA.121.181114.

• Hashimoto M, Takeichi K, Murata K, Kozakai A, Yagi A, Ishikawa K, Suzuki-Nakagawa C, Kasuya Y, Fukamizu A, Nakagawa T
  Regulation of neural stem cell proliferation and survival by protein arginine methyltransferase 1
  Front Neurosci. 10, 948517. (2022) doi: 10.3389/fnins.2022.948517.

2021

• Hashimoto M, Fukamizu A, Nakagawa T, and Kizuka Y.
  Roles of protein arginine methyltransferase 1 (PRMT1) in brain development and disease.
  Biochim. Biophys. Acta. 1865, 129776 (2021) doi: 10.1016/j.bbagen.2020.129776.

• Hashimoto M, Kumabe A, Kim JD, Murata K, Sowmya S, Williams A, Lu W, Ishida J, Nakagawa T, Endo M,
  Minami Y, and Fukamizu A.
  Loss of PRMT1 in the CNS induces reactive astrocytes and microglia during postnatal brain development.
  J. Neurochem. 156, 834-847 (2021) doi: 10.1111/jnc.15149.

• Ito M, Muramastu R, Kato Y, Sharma B, Uyeda A, Tanabe S, Fugimura H, Kidoya H, Takakura N, Kawahara Y, Takao M,
  Mochizuki H, Fukamizu A, and Yamashita T.
  Age-dependent decline in remyelination capacity is mediated by apeline-APJ signaling.
  Nature Aging 1, 284-294 (2021) doi : 10.1038/s43587-021-00041-7

• DinhTTH, Iseki H, Mizuno S, Iijima-Mizuno S, Tanimoto Y, Daitoku Y, Kato K, Hamada Y, Hassan ASH, Suzuki H, Murata K, Muratani M, Ema M, Kim JD, Ishida J, Fukamizu A, Kato M, Takahashi S, Yagami KI, Wilson V, Arkell RM and Sugiyama F.
  Distruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway.
  Elife 10:e50346 (2021) doi: 10.7554/eLife.50346.

• Watabe E, Togo-Ohno M, Ishigami Y, Wani S, Hirota K, Kimura-Asami M, Hasan S, Takei S, Fukamizu A, Suzuki Y, Suzuki T, and Kuroyanagi H.
  m6A-mediated alternative splicing coupled with nonsense-mediated mRNA decay regulates SAM synthetase homeostasis.
  EMBO J. e106434 (2021) doi: 10.15252/embj.2020106434.

• Satou-Kobayashi Y, Kim JD, Fukamizu A and Asashima M
  Temporal transcriptomic profiling reveals dynamic changes in gene expression of Xenopus anmimal cap upon activin treatment.
  Sci. Rep. 11(1):14537 (2021) doi: 10.1038/s41598-021-93524-x

• Daitoku H, Someya M, Kako K, Hayashi T, Tajima T, Haruki H, Sekiguchi N, Uetake T, Akimoto Y and Fukamizu A
  siRNA screening identifies METTL9 as a histidine N π-methyltransferase that targets the pro-inflammatory protein S100A9
   J. Biol. Chem. 101230 (2021) doi: 10.1016/j.jbc.2021.101230

• Uchiyama C, Fukuda A, Mukaiyama M, Nakazawa Y, Kuramochi Y, Muguruma K, Arimoto M, Ninomiya A, Kako K, Katsuyama Y, Konno S, Taguchi A, Takayama K, Taniguchi A, Nagumo Y, Usui T, Hayashi Y.
  Structural revision of natural cyclic depsipeptide MA026 established by total synthesis and biosynthetic gene cluster analysis.
  Angew Chem. Int. Ed. Engl. 60, 8792-8797. (2021) doi: 10.1002/anie.202015193

2020

• Matsuda S, Kim JD, Sugiyama F, Matsuo Y, Ishida J, Murata K, Nakamura K, Namiki K, Sudo T, Kuwaki T, Hatano M, Tatsumi K, Fukamizu A, and Kasuya Y.
  Transcriptomic evaluation of pulmonary fibrosis-related genes: Utilization of transgenic mice with modifying p38 signal in the lungs.
  Int. J. Mol. Sci. 21, E6746. (2020) doi: 10.3390/ijms21186746

• Fujimura A, Hayashi Y, Kato K, Kogure Y, Kameyama M, Shimamoto H, Daitoku H, Fukamizu A, Hirota T, and Kimura K.
  Identification of a novel nucleolar protein complex required for mitotic chromosome segregation through centromeric accumulation of Aurora B
  Nucleic Acids Res. 48, 6583-6596. (2020) doi: 10.1093/nar/gkaa449.

• Suzuki K, Kim JD, Ugai K, Matsuda S, Mikami H, Yoshioka K, Ikari J, Hatano M, Fukamizu A, Tatsumi K, and Kasuya Y.
  Transcriptomic changes involved in the dedifferentitation of myofibroblasts derived from the lung of a patient with idiopathic pulmonary fibrosis.
  Mol. Med. Rep. 22, 1518-1526 (2020) doi: 110.3892/mmr.2020.11218

• Hashimoto M, Hirata T, Yonekawa C, Takeichi K, Fukamizu A, Nakagawa T, and Kizuka Y.
  Region-specific upregulation of NHK-1 glycan in the PRMT1-deficient brain.
  Biochim. Biophys. Acta. 1864, 129509 (2020) doi:10.1016/j.bbagen.2019.129509

• Noguchi K*, Ishida J*, Kim JD, Muromachi N, Kako K, Mizukami H, Lu W, Ishimaru T, Kawasaki S, Kaneko S, Usui J, Ohtsu H, Yamagata K, and Fukamizu A.
  Histamine receptor agonist alleviates severe cardiorenal damages by eliciting anti-inflammatory programming.
  Proc. Natl. Acad. Sci. U. S. A. 117, 3150-3156 (2020) doi:10.1073/pnas.1909124117. *(equal contribution)

• Otani K, Tokudome T, Kamiya CA, Mao Y, Nishimura H, Hasegawa T, Arai Y, Kaneko M, Shioi G, Ishida J, Fukamizu A. Osaki T, Nagai-Okatani C, Minamino N, Ensho T, Hino J, Murata S, Takegami M, Nishimura K, Kishimoto I, Miyazato M, Harada-Shiba M, Yoshimatsu J, Nakao K, Ikeda T, and Kangawa K.
  Deficiency of cardiac natriuretic peptide signaling promotes peripartum cardiomyopathy-like remodeling in the mouse heart.
  Circulation 141, 571-588 (2020) doi: 10.1161/CIRCULATIONAHA.119.039761.

2019

• Nagano K, Kwon C, Ishida J, Hashimoto T, Kim JD, Kishikawa N, Murao M, Kimura K, Kasuya Y, Kimura S, Chen YC, Tsuchimochi H, Shirai M, Pearson J, and Fukamizu A.
  Cooperative action of APJ and α1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction.
  J. Biochem. 166, 383-392 (2019) doi:10.1093/jb/mvz071

• Lu W, Kim JD, Tabara S, Kwon C, Mizukami H, Kimura K, and Fukamizu A.
  The N-terminal sequence of murine PRMT5 variant 2 is required for Hsp70 interaction and CHIP ligase-mediated degradation.
  Biochem. Biophys Res. Commun. 514, 1185-1191 (2019) doi: 10.1016/j.bbrc.2019.05.077

• Hada K, Hirota K, Inanobe A, Kako K, Miyata M, Araoi S, Matsumoto M, Ohta R, Arisawa M, Daitoku H, Hanada T, and Fukamizu A.
  Tricarboxylic acid cycle activity suppresses acetylation of mitochondrial proteins during early embryonic development in Caenorhabditis elegans.
  J. Biol. Chem. 294, 3091-3099 (2019) doi:10.1074/jbc.RA118.004726

• Mizukami H, Kim JD, Tabara S, Lu W, Kwon C, Nakashima M, and Fukamizu A.
  KDM5D-mediated H3K4 demethylation is required for sexually dimorphic gene expression in mouse embryonic fibroblasts.
  J. Biochem. 165, 335-342 (2019) doi: 10.1093/jb/mvy106

• Kako K, Kim JD, and Fukamizu A.
  Emerging impacts of biological methylation on genetic information.
  J. Biochem. 165, 9-18 (2019) doi: 10.1093/jb/mvy075

2018

• Murata K, Lu W, Hashimoto M, Ono N, Muratani M, Nishikata K, Kim JD, Ebihara S, Ishida J, and Fukamizu A.
  PRMT1 Deficiency in Mouse Juvenile Heart Induces Dilated Cardiomyopayhy and Reveals Cryptic Alternative Splicing Products.
  iScience 8, 200-213 (2018) doi: 10.1016/j.isci.2018.09.023

• Ohkuro M, Kim JD, Kuboi Y, Hayashi Y, Mizukami H, Kobayashi-Kuramochi H, Muramoto K, Shirato M, Michikawa-Tanaka F, Moriya J, Kozaki T, Takase K, Chiba K, Agarwala KL, Kimura T, Kotake M, Kawahara T, Yoneda N, Hirota S, Azuma H, Ozasa-Komura N, Ohashi Y, Muratani M, Kimura K, Hishinuma I and Fukamizu A.
  Calreticulin and integrin alpha dissociation induces anti-inflammatory programming in animal models of inflammatory bowel disease.
  Nat. Commun. 9, 1982 (2018) doi: 10.1038/s41467-018-04420-4.
  ※ Nature INDEXにて、2018年10月のResearch Highlightとして、私達の研究が取り上げられました。
  (詳細はこちらをご覧ください。)

• Sato A, Kim JD, Mizukami H, Nakashima M, Kako K, Ishida J, Itakura A, Takeda S and Fukamizu A.
  Gestational changes in PRMT1 expression of murine placentas.
  Placenta 65, 47-54 (2018) doi: 10.1016/j.placenta.2018.04.001.

• Yokoyama W, Hirota K, Wan H, Sumi N, Miyata M, Araoi S, Nomura N, Kako K and Fukamizu A.
  rRNA adenine methylation requires T07A9.8 gene as rram-1 in Caenorhabditis elegans.
  J. Biochem. 163, 465-474 (2018) doi: 10.1093/jb/mvy018.

• Tóth EN, Lohith A, Mondal M, Guo J, Fukamizu A and Pourmand N.
  Single-cell nanobiopsy reveals compartmentalization of mRNA in neuronal cells.
  J. Biol. Chem. 293, 4940-4951 (2018) doi: 10.1074/jbc.M117.800763.

• Komiya H, Miyoshi C, Iwasaki K, Hotta-Hirashima N, Ikkyu A, Kanno S, Honda T, Gosho M, Hamada H, Satoh T, Fukamizu A, Funato H and Yanagisawa M.
  Sleep/wakefulness behaviors in mice during pregnancy and pregnancy-associated hypertensive mice.
  Sleep  41 (2018) doi: 10.1093/sleep/zsx209.

• Murakami S, Suzuki T, Yokoyama W, Yagi S, Matsumura K, Nakajima Y, Harigae H, Fukamizu A and Motohashi H.
  Nucleomethylin deficiency impairs embryonic erythropoiesis.
  J. Biochem. 163, 413-423 (2018)  doi: 10.1093/jb/mvx086.

• Araoi S, Daitoku H, Yokoyama A, Kako K, Hirota K and Fukamizu A.
  The GATA transcription factor ELT-2 modulates both the expression and methyltransferase activity of PRMT-1 in Caenorhabditis elegans.
  J. Biochem. 163, 433-440 (2018) doi: 10.1093/jb/mvy012.

• Ushiki A, Matsuzaki H, Fukamizu A and Tanimoto K.
  Homeostatic response of mouse renin gene transcription in a hypertensive environment is mediated by a novel 5' enhancer.
  Mol. Cell Biol. 38 (2018) doi: 10.1128/MCB.00566-17.
  • 【特許】第6320576号 深水昭吉, 金俊達, 萩原昌彦, 和田幸周
    発明の名称：細胞を分離、除去、及び解析する方法
  • 【特許】第6399874号 深水昭吉, 金俊達, 大黒理勝
    発明の名称：化合物の抗炎症効果または免疫抑制効果を予測する方法

2017

• Freyer L, Hsu CW, Nowotschin S, Pauli A, Ishida J, Kuba K, Fukamizu A, Schier AF, Hoodless PA, Dickinson ME and Hadjantonakis AK.
  Loss of apela peptide in mice causes low penetrance embryonic lethality and defects in early mesodermal derivatives.
  Cell Rep. 20, 2116-2130 (2017) doi: 10.1016/j.celrep.2017.08.014.

• Matsuda T, Hiyama TY, Niimura F, Matsusaka T, Fukamizu A, Kobayashi K, Kobayashi K and Noda M.
  Erratum: Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ.
  Nat Neurosci. 20, 896. (2017)  doi: 10.1038/nn0617-896b.

• Nezu M, Souma T, Yu L, Sekine H, Takahashi N, Wei AZ, Ito S, Fukamizu A, Zsengeller ZK, Nakamura T, Hozawa A, Karumanchi SA, Suzuki N, and Yamamoto M.
  Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes.
  Science Signal. 10, eaam5711 (2017) doi: 10.1126/scisignal.aam5711.

• Sato T, Sato C, Kadowaki A, Watanabe H, Ho L, Ishida J, Yamaguchi T, Kimura A, Fukamizu A, Penninger JM, Reversade B, Ito H, Imai Y, and Kuba K.
  ELABELA - APJ axis protects from pressure overload heart failure and Angiotensin II-induced cardiac damage.
  Cardiovasc. Res. 113, 760-769 (2017) doi: 10.1093/cvr/cvx061.

• Yagishita Y, Uruno A, Fukutomi T, Saito R, Saigusa D, Pi J, Fukamizu A, Sugiyama F, Takahashi S, and Yamamoto M.
  Nrf2 improves leptin and insulin resistance provoked by hypothalamic oxidative stress.
  Cell Rep. 18, 2030-2044 (2017) doi: 10.1016/j.celrep.2017.01.064.

• Kanou A, Kako K, Hirota K, and Fukamizu A.
  PRMT-5 converts monomethylarginines into symmetrical dimethylarginines in Caenorhabditis elegans.
  J. Biochem. 161, 231-235 (2017) doi: 10.1093/jb/mvw066

• Hirota K, Shigekawa C, Araoi S, Sha L, Inagawa T, Kanou A, Kako K, Daitoku H, and Fukamizu A.
  Simultaneous ablation of prmt-1 and prmt-5 abolishes asymmetric and symmetric arginine dimethylations in Caenorhabditis elegans.
  J. Biochem. 161, 521-527 (2017) doi: 10.1093/jb/mvw101.

• Taniguchi H, Okamuro S, Kohji M, Waku T, Hatanaka A, Sun Y, Chowdhury A, Fukamizu A, and Kobayashi A.
  Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes.
  Biochem. Biophys. Res. Commun. 484, 176-183 (2017) doi: 10.1016/j.bbrc.2017.01.038

• Kawasaki S, Kako K, Nagashima Y, Kanou A, Ishida J, and Fukamizu A.
  Hydralazine is involved in tele-methylhistamine metabolism by inhibiting monoamine oxidase B in pregnancy-associated hypertensive mice.
  J. Biochem. 161, 155-158 (2017) doi: https://doi.org/10.1093/jb/mvw090

• Ishimaru T, Ishida J, Kim JD, Mizukami H, Hara K, Hashimoto M, Yagami KI, Sugiyama F, and Fukamizu A.
  Angiodysplasia in embryo lacking protein arginine methyltransferase 1 (PRMT1) in vascular endothelial cells.
  J. Biochem. 161, 255-258 (2017) doi: https://doi.org/10.1093/jb/mvw095

• Sha L, Daitoku H, Araoi S, Kaneko Y, Takahashi Y, Kako K, and Fukamizu A.
  Asymmetric arginine dimethylation modulates mitochondrial energy metabolism and homeostasis in Caenorhabditis elegans.
  Mol. Cell. Biol. 37, e00504-16 (2017) doi: 10.1128/MCB.00504-16

• Matsuda T, Hiyama TY, Niimura F, Matsusaka T, Fukamizu A, Kobayashi K, Kobayashi K, and Noda M.
  Distinct neural mechanisms for the control of thirst and salt appetite in the subfornical organ.
  Nature Neurosci. 20, 230-241 (2017) doi: 10.1038/nn.4463

2016

• Ushiki A, Matsuzaki H, Ishida J, Fukamizu A, and Tanimoto K.
  Long-range control of renin gene expression in Tsukuba hypertensive mice
  PLoS One. 11, e0166974 (2016)

• Egashira Y, Takase M, Watanabe S, Ishida J, Fukamizu A, Kaneko R, Yanagawa Y, and Takamori S.
  Unique pH dynamics in GABAergic synaptic vesicles illuminates the GABA transport mechanism.
  Proc. Natl. Acad. Sci. U S A. 113, 10702-10707 (2016)

• Daitoku H, Kaneko Y, Yoshimochi K, Matsumoto K, Araoi S, Sakamaki J, Takahashi Y, and Fukamizu A.
  Non-transcriptional function of FOXO1/DAF-16 contributes to translesion DNA synthesis.
  Mol. Cell. Biol. 36, 2755-2766 (2016)

• Doura T, Kamiya M, Obata F, Yamaguchi Y, Hiyama TY, Matsuda T, Fukamizu A, Noda M, Miura M, and Urano Y.
  Detection of LacZ-positive cells in living tissue with single-cell resolution.
  Angew. Chem. 55, 9620-9624 (2016)

• Sasaki T, Tanaka Y, Kulkeaw K, Yumine-Takai A, Tan KS, Nishinakamura R, Ishida J, Fukamizu A, and Sugiyama D.
  Embryonic intra-aortic clusters undergo myeloid differentiation mediated by mesonephros-derived CSF1 in mouse.
  Stem Cell Rev. 12, 530-542 (2016)

• Waku T, Nakajima Y, Yokoyama W, Nomura N, Kako K, Kobayashi A, Shimizu T, and Fukamizu A.
  NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner.
  J. Cell Sci. 129, 2382-2393 (2016)

• Kaneko Y, Daitoku H, Komeno C, and Fukamizu A.
  CTF18 interacts with replication protein A in response to replication stress.
  Mol. Med. Rep. 14, 367-372 (2016)

• Murata K, Ishida J, Ishimaru T, Mizukami H, Hamada J, Saito C, and Fukamizu A
  Lactation is a risk factor of postpartum heart failure in mice with cardiomyocyte-specific apelin receptor (APJ) overexpression.
  J. Biol. Chem. 291, 11241-11251 (2016)

• Itoh Y, Fuchino H, Sanosaka M, Kako K, Hada K, Fukamizu A, Takemori H, and Kawahara N.
  Pterosin B has multiple targets in gluconeogenic programs, including coenzyme Q in RORα-SRC2 signaling.
  Biochem. Biophys. Res. Commun. 473, 415-420 (2016)

• Shimbo M, Kudo T, Hamada M, Jeon H, Imamura Y, Asano K, Okada R, Tsunakawa Y, Mizuno S, Yagami K, Ishikawa C, Li H, Shiga T, Ishida J, Hamada J, Murata K, Ishimaru T, Hashimoto M, Fukamizu A, Yamane M, Ikawa M, Morita H, Shinohara M, Asahara H, Kiyama T, Akiyama N, Sasanuma H, Yoshida N, Zhou R, Wang Y, Ito T, Kokubu Y, Noguchi T, Ishimine H, Kurisaki A, Shiba D, Mizuno H, Shirakawa M, Ito N, Takeda S, and Takahashi S.
  Ground-based assessment o JAXA mouse habitat cage unit by mouse phenotypic studies
  Exp. Anim. 65, 175-187 (2016)

• Toma-Fukai S, Kim JD, Park KE, Kuwabara N, Shimizu N, Krayukuhina E, Uchiyama S, Fukamizu A, and Shimizu T.
  Novel helical assembly in arginine methyltransferase 8
  J. Mol. Biol. 428, 1197-1208 (2016)

• Hashimoto M, Murata K, Ishida J, Kanou A, Kasuya Y, and Fukamizu A.
  Severe hypomyelination and developmental defects are caused in mice lacking protein arginine methyltransferase 1 (PRMT1) in the central nervous system.
  J. Biol. Chem. 291, 2237-2245 (2016)

2015

• Komura-Kawa T, Hirota K, Shimada-Niwa Y, Yamauchi R, Shimell M, Shinoda T, Fukamizu A, O'Connor MB, Niwa R.
  The Drosophila Zinc Finger Transcription Factor Ouija Board Controls Ecdysteroid Biosynthesis through Specific Regulation of spookier.
  PLoS Genet. 11, e1005712 (2015) doi: 10.1371/journal.pgen.1005712

• Kim JD, Park KE, Ishida J, Kako K, Hamada J, Kani S, Takeuchi M, Namiki K, Fukui H, Fukuhara S, Hibi M, Kobayashi M, Kanaho Y, Kasuya Y, Mochizuki N, and Fukamizu A.
  PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination
  Science Adv. 1, e1500615 (2015) doi: 10.1126/sciadv.1500615

• Matsuzaki H, Okamura E, Takahashi T, Ushiki A, Nakamura T, Nakano T, Hata K, Fukamizu A, and Tanimoto K.
  De novo DNA methylation through 5'-segment of the H19 ICR maintains its imprint during early embryogenesis.
  Development 142, 3833-3844 (2015) doi: 10.1242/dev.126003.

• Kako K, Nakamura A, Nagashima Y, Ishida J, and Fukamizu A.
  Detection of ethanolamine altering in fetuses of pregnancy-associated hypertensive mice treated with vasodepressors by using UPLC and MALDI-TOF/MS
  J. Chromatogr. B 1006, 93-98 (2015) doi: 10.1016/j.jchromb.2015.10.018.

• Murata K, Baasanjav A, Kwon C, Hashimoto M, Ishida J, and Fukamizu A.
  Angiotensin II accelerates mammary gland development independently of high blood pressure in pregnancy-associated hypertensive mice.
  Physiol. Rep. 3, e12542 (2015) doi: 10.14814/phy2.12542.

• Hara S, Kobayashi N, Sakamoto K, Ueno T, Manabe S, Takashima Y, Hamada J, Pastan I, Fukamizu A, Matsusaka T, and Nagata M.
  Podocyte injury-driven lipid peroxidation accelerates the infiltration of glomerular foam cells in focal segmental glomerulosclerosis.
  Am. J. Pathol. 185, 2118-2131 (2015) doi: 10.1016/j.ajpath.2015.04.007.

• Kato H, Ishida J, Matsusaka T, Ishimaru T, Tanimoto K, Sugiyama F, Yagami K, Nangaku M, and Fukamizu A.
  Erythropoiesis and blood pressure are regulated via AT1 receptor by distinctive pathways.
  PLoS One 10, e0129484 (2015) doi: 10.1371/journal.pone.0129484.

• Hamada J, Baasanjav A, Ono N, Murata K, Kako K, Ishida J, and Fukamizu A
  Possible involvement of downregulation of the apelin-APJ system in doxorubicin-induced cardiotoxicity.
  Am. J. Physiol. Heart Circ. Physiol. 308, H931-941 (2015) doi: 10.1152/ajpheart.00703.2013.

• Kidoya H, Naito H, Muramatsu F, Yamakawa D, Jia W, Ikawa M, Sonobe T, Tsuchimochi H, Shirai M, Adams RH, Fukamizu A, and Takakura N.
  APJ regulates parallel alignment of arteries and veins in the skin.
  Dev. Cell 33, 247-259 (2015) doi: 10.1016/j.devcel.2015.02.024.

2014

• Tanimoto K, Kanafusa S, Ushiki A, Matsuzaki H, Ishida J, Sugiyama F, and Fukamizu A
  A mouse renin distal enhancer is essential for blood pressure homeostasis in BAC-rescued renin-null mutant mice.
  J. Recept. Signal Transduct. 34, 401-409 (2014) doi: 10.3109/10799893.2014.908917.

• Hasegawa M, Toma-Fukai S, Kim JD, Fukamizu A, and Shimizu T
  Protein arginine methyltransferase 7 has a novel homodimer-like structure formed by tandem repeats.
  FEBS Lett. 58, 1042-1048 (2014) doi: 10.1016/j.febslet.2014.03.053.

• Park KE, Kim JD, Nagashima Y, Kako K, Daitoku H, Matsui M, Park GG, and Fukamizu A
  Detection of choline and phosphatidic acid (PA) catalyzed by Phospholipase D (PLD)
  using MALDI-QIT-TOF/MS with 9-aminoacridine matrix
  Biosci. Biotechnol. Biochem. 78, 981-988 (2014) doi: 10.1080/09168451.2014.910102.

• Shin-ichiro Yasuda and Junji Ishida
  GPR39-1b, the 5-transmembrane isoform of GPR39 interacts with neurotensin receptor NTSR1
  and modifies its function
  J. Recept. Signal Transduct. 34, 307-312 (2014) doi: 10.3109/10799893.2014.885050.

• Amano H, Murata K, Matsunaga H, Tanaka K, Yoshioka K, Kobayashi T, Ishida J, Fukamizu A, Sugiyama F, Sudo T, Kimura S, Tatsumi K, and Kasuya Y.
  p38 Mitogen-activated protein kinase accelerates emphysema in mouse model of chronic obstructive pulmonary disease.
  J. Recept. Signal Transduct. 34, 299-306 (2014) doi:10.3109/10799893.2014.896380.

2013

• Mizuno S, Tra DT, Mizobuchi A, Iseki H, Mizuno-Iijima S, Kim JD, Ishida J, Matsuda Y, Kunita S, Fukamizu A, Sugiyama F, and Yagami KI.
  Truncated Cables1 causes agenesis of the corpus callosum in mice.
  Lab. Invest. 94, 321-330 (2014) doi: 10.1038/labinvest.2013.146.

• Sato T, Suzuki T, Watanabe H, Kadowaki A, Fukamizu A, Liu PP, Kimura A, Ito H, Penninger JM,
  Imai Y, and Kuba K.
  Apelin is a positive regulator of ACE2 in failing hearts.
  J. Clin. Invest. 123, 5203-5211 (2013) doi: 10.1172/JCI69608.

• Okamura E, Matsuzaki H, Fukamizu A, and Tanimoto K.
  The chicken HS4 insulator element does not protect the H19 ICR from differential DNA methylation in yeast artificial chromosome transgenic mouse.
  PLoS One 8, e73925 (2013) doi: 10.137/journal.pone.0073925.

• Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, and Hirose S.
  Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D.
  PLoS One 8, e69451 (2013) doi: 10.1371/journal.pone.0069451.

• Sakaguchi R, Okamura E, Matsuzaki H, Fukamizu A, and Tanimoto K.
  Sox-Oct motifs contribute to maintenance of the unmethylated H19 ICR in YAC transgenic mice.
  Hum. Mol. Genet. 22, 4627-4637 (2013) doi: 10.1093/hmg/ddt311.

• Tamiya H, Hirota K, Takahashi Y, Daitoku H, Kaneko Y, Sakuta G, Iizuka K, Watanabe S, Ishii N,
  and Fukamizu A.
  Conserved SAMS function in regulating egg-laying in C. elegans.
  J. Recept. Signal Transduct. 33, 56-62 (2013) doi: 10.3109/10799893.2012.756896.

• Murata K, Saito C, Ishida J, Hamada J, Sugiyama F, Yagami K, and Fukamizu A.
  Effect of lactation on postpartum cardiac function of pregnancy-associated hypertensive mice.
  Endocrinology 154, 597-602 (2013) doi: 10.1210/en.2012-1789.

• Nagano K, Ishida J, Unno M, Matsukura T, and Fukamizu A.
  Apelin elevates blood pressure in ICR mice with L-NAME-induced endothelial dysfuncsion.
  Mol. Med. Rep. 7, 1371-1375 (2013) doi: 10.3892/mmr.2013.1378.

• Okamura E, Matsuzaki H, Sakaguchi R, Takahashi T, Fukamizu A, and Tanimoto K.
  The h19 imprinting control region mediates preimplantation imprinted methylation of nearby sequences in yeast artificial chromosome transgenic mice.
  Mol. Cell. Biol. 33, 858-871 (2013) doi: 10.1128/MCB.01003-12.

• Amano H, Ito Y, Ogawa F, Eshima K, Suzuki T, Oba K, Matsui Y, Kato S, Fukui T, Nakamura M, Kitasato H, Fukamizu A, and Majima M.
  Angiotensin II type 1A receptor signaling facilitates tumor metastasis formation through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells.
  Am. J. Pathol. 182, 553-564 (2013) doi: 10.1016/j.ajpath.2012.10.026.

2012

• Nagashima Y, Kako K, Kim JD, and Fukamizu A.
  Enhanced histamine production through the induction of histidine decarboxylase expression by phorbol ester in Jurkat cells
  Mol. Med. Rep. 6, 944-948 (2012) doi: 10.3892/mmr.2012.1049.

• Takahashi T, Matsuzaki H, Tomizawa S, Okamura E, Ichiyanagi T, Fukamizu A, Sasaki H, and Tanimoto K.
  Sequences in the H19 ICR that are transcribed as small RNA in oocytes are dispensable for methylation imprinting in YAC transgenic mice.
  Gene 508, 26-34 (2012) doi: 10.1016/j.gene.2012.07.062.

• Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, Sigl V, Hanada T, Hanada R, Lipinski S, Wild B, Camargo SM, Singer D, Richter A, Kuba K, Fukamizu A, Schreiber S, Clevers H, Verrey F, Rosenstiel P, and Penninger JM.
  ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.
  Nature 487, 477-481 (2012) doi: 10.1038/nature11228.

• Namiki K, Matsunaga H, Yoshioka K, Tanaka K, Murata K, Ishida J, Sakairi A, Kim J, Tokuhara N, Shibakawa N, Shimizu M, Wada Y, Tokunaga Y, Shigetomi M, Hagihara M, Kimura S, Sudo T, Fukamizu A, and Kasuya Y.
  Mechanism for p38α-mediated experimental autoimmune encephalomyelitis
  J. Biol. Chem. 287, 24228-24238 (2012) doi: 10.1074/jbc.M111.338541.

• Ishimaru T, Ishida J, Nakamura S, Hashimoto M, Matsukura T, Nakamura A, Kunita S, Sugiyama F, Yagami K, and Fukamizu A.
  Short-term suppression of the renin-angiotensin system in mice associated with hypertension during pregnancy
  Mol. Med. Rep. 6, 28-32 (2012) doi: 10.3892/mmr.2012.886.

• Hokari Y, Seki T, Nakano H, Matsuo Y, Fukamizu A, Munekata E, Kiso Y, and Mukai H.
  Isolation and identification of novel neutrophil-activating cryptides hidden in mitochondrial cytochrome C
  Protein Pept. 19, 680-687 (2012)

• Ozcan L, Wong CC, Li G, Xu T, Pajvani U, Park SK, Wronska A, Chen BX, Marks AR, Fukamizu A, Backs J, Singer HA, Yates JR 3rd, Accili D, and Tabas I.
  Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.
  Cell Metab. 15, 739-751 (2012) doi: 10.1016/j.cmet.2012.03.002.

• Sakimoto S, Kidoya H, Naito H, Kamei M, Sakaguchi H, Goda N, Fukamizu A, Nishida K, and Takakura N.
  A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice
  Development 139, 1327-1335 (2012) doi: 10.1242/dev.072330.

• Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K,
  Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M, and Mochizuki N.
  The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice.
  J. Clin. Invest. 122, 1416-1426 (2012) doi: 10.1172/JCI60746.

• Sakamaki JI, Daitoku H, Kaneko Y, Hagiwara A, Ueno K, and Fukamizu, A.
  GSK3β regulates gluconeogenic gene expression through HNF4a and FOXO1.
  J. Recept. Signal Transduct. 32, 96-101 (2012) doi: 10.3109/10799893.2012.660531.

2011

• Kaneko K, Ito M, Fumoto T, Fukuhara R, Ishida J, Fukamizu A, and Ikeda K.
  Physiological function of the angiotensin AT1a receptor in bone remodeling
  J. Bone Miner. Res. 26, 2959-2966 (2011) doi: 10.1002/jbmr.501.

• Ishida J, Matsuoka T, Saito-Fujita T, Inaba S, Kunita S, Sugiyama F, Yagami KI, and Fukamizu A.
  Pregnancy-associated homeostasis and dysregulation: Lessons from genetically modified animal models
  J. Biochem. 150, 5-14 (2011) doi: 10.1093/jb/mvr069.

• Shirakawa T, Kako K, Shimada T, Nagashima Y, Nakamura A, Ishida J, and Fukamizu A.
  Production of free methylarginines via the proteasome and autophagy pathways in cultured cells
  Mol. Med. Re. 4, 615-620 (2011) doi: 10.3892/mmr.2011.488.

• Kobayashi A, Tsukide T, Miyasaka T, Morita T, Mizoroki T, Saito Y, Ihara Y, Takashima A, Noguchi N, Fukamizu A, Hirotsu Y, Ohtsuji M, Katsuoka F, and Yamamoto M.
  Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.
  Genes Cells 16, 692-703 (2011) doi: 10.1111/j.1363-2443.2011.01522.x.

• Takahashi Y, Daitoku H, Hirota K, Tamiya H, Yokoyama A, Kako K, Nagashima Y, Nakamura A, Shimada T, Watanabe S, Yamagata K, Yasuda K, Ishii N, and Fukamizu A.
  Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16.
  Cell Metab. 13, 505-516 (2011) doi: 10.1016/j.cmet.2011.03.017.

• Nakajima Y, Akaogi K, Suzuki T, Osakabe A, Yamaguchi C, Sunahara N, Ishida J, Kako K, Ogawa S,
  Fujimura T, Homma Y, Fukamizu A, Murayama A, Kimura K, Inoue S, and Yanagisawa J.
  Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5.
  Sci. Signal. 4, ra22 (2011) doi: 10.1126/scisignal.2001551.

• Sakamaki JI, Daitoku H, Ueno K, Hagiwara A, Yamagata K, and Fukamizu A.
  Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt.
  Proc. Natl. Acad. Sci. U S A. 108, 6085-6090 (2011) doi: 10.1073/pnas.1015328108.

• Daitoku H, Sakamaki JI, and Fukamizu A.
  Regulation of FoxO transcription factors by acetylation and protein-protein interactions
  Biochem. Biophys. Acta. 1813, 1954-1960 (2011) doi: 10.1016/j.bbamcr.2011.03.001.

• Takahashi Y, Daitoku H, Yokoyama A, Nakayama K, Kim, JD, and Fukamizu A.
  The C. elegans PRMT-3 possesses a type III protein arginine methyltransferase activity.
  J. Recept. Signal Transduct. 31, 168-172 (2011) doi: 10.3109/10799893.2011.555768.

• Seki T, Fukamizu A, Kiso Y, and Mukai H.
  Mitocryptide-2, a neutrophil-activating cryptide, is a specific endogenous agonist for formyl-peptide receptor-like 1.
  Biochem. Biophys. Res. Commun. 404, 482-487 (2011) doi: 10.1016/j.bbrc.2010.12.007.

2010

• Hirota K and Fukamizu A.
  Transcriptional regulation of energy metabolism in the liver
  J. Recept. Signal. Transduct. 30, 403-409 (2010) doi: 10.3109/10799893.2010.509703. 

• Toro R, Prahst C, Mathivet T, Siegfried G, Kaminker J, Larrivee B, Breant C, Duarte A, Takakura N,
  Fukamizu A, Penninger J, and Eichmann A.
  Identification and functional analysis of endothelial tip cell-enriched genes
  Blood 116, 4025-4033 (2010) doi: 10.1182/blood-2010-02-270819.

• Oishi T, Date S, Shimamoto Y, Saito T, Hirota K, Sugaya T, Kon Y, Fukamizu A, and Tanimoto K.
  A nuclear receptor, hepatocyte nuclear factor 4, differently contributes to the human and mouse angiotensinogen promoter activities.
  J. Recept. Signal Transduct. 30, 484-492 (2010) doi: 10.3109/10799893.2010.505240.  

• Shimotsuma M, Okamura E, Matsuzaki H, Fukamizu A, and Tanimoto K.
  DNAse I hypersensitivity and {epsilon}-globin transcriptional enhancement are separable in LCR HS1 mutant human {beta}-globin YAC transgenic mice.
  J. Biol. Chem. 285, 14495-14503 (2010) doi: 10.1074/jbc.M110.116525.

• Du W, Takuwa N, Yoshioka K, Okamoto Y, Gonda K, Sugihara K, Fukamizu A, Asano M, and Takuwa Y.
  S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice.
  Cancer Res. 70, 772-781 (2010) doi: 10.1158/0008-5472.CAN-09-2722.

• Fukamizu A.
  A new codified regulation of arginine methylation and Akt-induced phosphorylation
  Tanpakushitsu Kakusan Koso. 55, 69-73 (2010) Review

• Matsuzaki H, Okamura E, Fukamizu A, and Tanimoto K.
  CTCF binding is not the epigenetic mark that establishes post-fertilization methylation imprinting in the transgenic H19 ICR.
  Hum. Mol. Genet. 19, 1190-1198 (2010) doi: 10.1093/hmg/ddp589.

• Yoshimochi K, Daitoku H, and Fukamizu A.
  PCAF represses transactivation function of FOXO1 in an acetyltransferase-independent manner.
  J. Recept. Signal Transduct. 30,43-49 (2010) doi: 10.3109/10799890903517947.

• Sugawara M, Okamoto K, Kadowaki T, Kusano K, Fukamizu A, and Yoshimura T.
  Expressions of cytochrome P450, UDP-glucuronosyltranferase, and transporter genes in monolayer carcinoma cells change in subcutaneous tumors grown as xenografts in immunodeficient nude mice.
  Drug Metab. Dispos. 38, 526-533 (2010) doi: 10.1124/dmd.109.030668.

• Kamide K, Nakakubo H, Uno S, and Fukamizu A.
  Isolation of novel cell-penetrating peptides from a random peptide library using in vitro virus and their modifications
  Int. J. Mol. Med. 25, 41-51 (2010)

2009

• Araya N, Arimura H, Kawahara K, Yagishita N, Ishida J, Fujii R, Aratani S, Fujita H, Sato T, Yamano Y, Higuchi I, Osame M, Nishioka K, Fukamizu A, Arimura K, Maruyama I, and Nakajima T.
  Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase
  Int. J. Mol. Med. 24, 605-611 (2009) doi: 10.3892/ijmm_00000271.

• Okamura E, Matsuzaki H, Campbell AD, Engel JD, Fukamizu A, and Tanimoto K.
  All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic mice
  FASEB J. 23, 4335-4343 (2009) doi: 10.1096/fj.09-137778.

• Sugawara M, Okamoto K, Kadowaki T, Kusano K, Fukamizu A, and Yoshimura T.
  Inoculation of human tumor cells alters the basal expression but not the inducibility of Cyp enzymes in tumor-bearing mouse liver
  Drug Metab. Dispos. 37, 2244-2254 (2009) doi: 10.1124/dmd.109.028571.

• Matsuzaki H, Okamura E, Shimotsuma M, Fukamizu A, and Tanimoto K.
  A randomly integrated transgenic H19 imprinting control region acquires methylation imprinting independently of its establishment in germ cells
  Mol. Cell. Biol. 29, 4595-4603 (2009) doi: 10.1128/MCB.00275-09.

• Kurosaka M, Suzuki T, Hosono K, Kamata Y, Fukamizu A, Kitasato H, Fujita Y, and Majima M.
  Reduced angiogenesis and delay in wound healing in angiotensin II type 1a receptor-deficient mice
  Biomed. Pharmacother. 63, 627-634 (2009) doi: 10.1016/j.biopha.2009.01.001.

• Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, Tsubota K, Itoh H, Oike Y, and Ishida S.
  (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes induced retinal inflammation
  Diabetes 58, 1625-1633 (2009) doi: 10.2337/db08-0254.

• Sakamaki J, Daitoku H, Yoshimochi K, Miwa M, and Fukamizu A.
  Regulation of FOXO1-mediated transcription and cell proliferation by PARP-1
  Biochem. Biophys. Res. Commun. 382, 497-502 (2009) doi: 10.1016/j.bbrc.2009.03.022.

• Sako K, Fukuhara S, Minami T, Hamakubo T, Song H, Kodama T, Fukamizu A, Gutkind JS, Koh GY, and Mochizuki N.
  Angiopoietin-1 induces Kruppel-like factor 2 expression through a phosphoinositide 3-kinase/AKT-dependent activation of myocyte enhancer factor 2
  J. Biol. Chem. 284, 5592-5601 (2009) doi: 10.1074/jbc.M806928200.

• Furuya M, Ishida J, Aoki I, and Fukamizu A.
  Pathophysiology of placentation abnormalities in pregnancy-induced hypertension
  Vasc. Health Risk Manag. 4 , 1301-1313 (2009) Review

• Hara Y, Onishi Y, Oishi K, Miyazaki K, Fukamizu A, and Ishida N.
  Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter
  Nucleic Acids Res. 37, 1115-1126 (2009) doi: 10.1093/nar/gkn1013.

• Ito Y, Daitoku H, and Fukamizu A.
  Foxo1 increases pro-inflammatory gene expression by inducing C/EBPβ in TNF-α-treated adipocytes
  Biochem. Biophys. Res. Commun. 378, 290-295 (2009) doi: 10.1016/j.bbrc.2008.11.043.

• Asaba Y, Ito M, Fumoto T, Watanabe K, Fukuhara R, Takeshita S, Nimura Y, and Ishida J,
  Fukamizu, A., and Ikeda, K.
  Activation of renin-angiotensin system induces osteoporosis independently of hypertension
  J. Bone Miner. Res. 24, 241-250, (2009) doi: 10.1359/jbmr.081006.

2008

• Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, Tsubota K, Itoh H, Oike Y, and Ishida S.
  (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system.
  Am. J. Pathol. 173, 1911-1918 (2008) doi: 10.2353/ajpath.2008.080457

• Sakairi A, Ishida J, Honjo K, Inaba S, Nakamura S, Sugiyama F, Yagami K, and Fukamizu A.
  Angiotensin type 1 receptor blockade prevents cardiac remodeling in mice with pregnancy-associated hypertension.
  Hypertension Res. 31 2165-2175 (2008) doi: 10.1291/hypres.31.2165

• Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, and Fukamizu, A.
  Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Mol. Cell 32, 221-231(2008) doi: 10.1016/j.molcel.2008.09.013

• Hirota K, Sakamaki J. Ishida J, Shimamoto Y, Nishihara S, Kodama N, Ohta K, Yamamoto M, Tanimoto K, and Fukamizu A.
  A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding.
  J. Biol. Chem. 283, 32432-32441 (2008) doi: 10.1074/jbc.M806179200

• Hamada J, Kimura J, Ishida J, Kohda T, Morishita S, Ichihara S, and Fukamizu A.
  Evaluation of novel cyclic analogues of apelin.
  Int. J. Mol. Med. 22, 547-552 (2008) doi: 10.3892/ijmm_00000054

• Yayama K, Miyagi R, Sugiyama K, Sugaya T, Fukamizu A, and Okamoto H.
  Angiotensin II regulates liver regeneration via type 1 receptor following partial hepatectomy in mice.
  Biol. Pharm. Bull. 31, 1356-1361 (2008) doi: 10.1248/bpb.31.1356

• Asada S, Ikeda A, Nagao R, Hama H, Sudo T, Fukamizu A, Kasuya Y, and Kishi T.
  Oxidative stress-induced ubiquitination of RCAN1 mediated by SCFbeta-TrCP ubiquitin ligase.
  Int. J. Mol. Med. 22, 95-104 (2008) doi: 10.3892/ijmm.22.1.95

• Murayama A, Ohmori K, Fujimura A, Minami H, Yasuzawa-Tanaka K, Kuroda T, Oie S, Daitoku H, Okuwaki M, Nagata K, Fukamizu A, Kimura K, Shimizu T, and Yanagisawa J.
  Epigenetic control of rDNA loci in response to intracellular energy status.
  Cell 133, 627-639 (2008) doi: 10.1016/j.cell.2008.03.030

• Kim JD, Kako K, Kakiuchi, M, Park GG, and Fukamizu A.
  EWS is a substrate of type I protein arginine methyltransferase, PRMT8.
  Int. J. Mol. Med. 22,309-315 (2008) doi: 10.3892/ijmm_00000024

• Ohno, O, Ye M, Koyama T, Yazawa K, Mura E, Matsumoto H, Ichino T, Yamada K, Nakamura K, Ohno T, Yamaguchi K, Ishida J, Fukamizu A, and Uemura D.
  Inhibitory effects of benzyl benzoate and its derivatives on angiotensin II-induced hypertension
  Bioorg. Med. Chem. 16, 7843-7852 (2008) doi: 10.1016/j.bmc.2008.03.056.

• Kato H, Ishida J, Nagano K, Honjo K, Sugaya T, Takeda N, Sugiyama F, Yagami K, Fujita T, Nangaku M, and Fukamizu A.
  Deterioration of atherosclerosis in mice lacking angiotensin II type 1A receptor in bone marrow-derived cells
  Lab. Invest. 88, 731-739 (2008) doi: 10.1038/labinvest.2008.42

• Tanimoto K, Sugiura A, Kanafusa S, Saito T, Masui N, Yanai K, and Fukamizu A.
  A single nucleotide mutation in the mouse renin promoter disrupts blood pressure regulation
  J. Clin. Invest. 118, 1006-1016 (2008) doi: 10.1172/JCI33824

• Lu H, Rateri DL, Feldman DL, Jr. RJ, Fukamizu A, Ishida J, Oesterling EG, Cassis LA, and Daugherty A.
  Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice
  J. Clin. Invest. 118, 984-993 (2008) doi: 10.1172/JCI32970

• Furuya M, Ishida J, Inaba S, Kasuya Y, Kimura S, Nemori R, and Fukamizu A.
  Impaired placental neovascularization in mice with pregnancy-associated hypertension
  Lab. Invest. 88, 416-429 (2008) doi: 10.1038/labinvest.2008.7

2007

• Hashimoto T, Kihara M, Imai N, Yoshida S, Shimoyamada H, Yasuzaki H, Ishida J, Toya Y, Kiuchi Y, Tamura K, Yazawa T, Kitamura H, Fukamizu A, and Umemura S.
  Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis
  Am. J. Pathol. 171, 1705-1712 (2007) doi:10.2353/ajpath.2007.070471

• Umemura M, Fujita M, Yoko-O T, Fukamizu A, and Jigami Y.
  Saccharomyces cerevisiae CWH43 is involved in the remodeling of the lipid moiety of GPI anchors to ceramides.
  Mol. Biol. Cell 18, 4304- 4316 (2007)

• Nakanishi M, Harada M, Kishimoto I, Kuwahara K, Kawakami R, Nakagawa Y, Yasuno S, Usami S, Kinoshita H, Adachi Y, Fukamizu A, Saito Y, and Nakao K.
  Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation.
  Circ. J. 71, 1310-1316 (2007)

• Daitoku H, and Fukamizu A.
  FOXO Transcription Factors in the Regulatory Networks of Longevity
  J. Biochem. 141, 769-774 (2007) Review

• Zhang J, Hosoya T, Maruyama A, Nishikawa K, Maher JM, Ohta T, Motohashi H, Fukamizu A, Shibahara S, Itoh K, and Yamamoto M.
  Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes.
  Biochem J. 404, 459-466 (2007) doi: 10.1042/BJ20061611

• Sekine K, Chen YR, Kojima N, Ogata K, Fukamizu A, and Miyajima A.
  Foxo1 links insulin signaling to C/EBPa and regulates gluconeogenesis during liver development.
  EMBO J. 15, 3607-3615 (2007) doi: 10.1038/sj.emboj.7601784

• Shimotsuma M, Matsuzaki H, Tanabe O, Campbell AD, Engel JD, Fukamizu A, and Tanimoto K.
  Linear distance from the locus control region determines epsilon-globin transcriptional activity.
  Mol. Cell. Biol. 16, 5664-5672 (2007) doi: 10.1128/MCB.00602-07

• Yamasaki S, Yagishita N, Sasaki T, Nakazawa M, Kato Y, Yamadera T, Bae E, Toriyama S, Ikeda R, Zhang L, Fujitani K, Yoo E, Tsuchimochi K, Ohta T, Araya N, Fujita H, Aratani S, Eguchi K, Komiya S, Maruyama I, Higashi N, Sato M, Senoo H, Ochi T, Yokoyama S, Amano T, Kim J, Gay S, Nishioka K, Fukamizu A, Tanaka K, and Nakajima T.
  Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.
  EMBO J. 26, 113-122 (2007) doi: 10.1038/sj.emboj.7601490

• Fan W, Yanase T, Morinaga H, Okabe T, Nomura M, Daitoku H, Fukamizu A, Kato S, Takayanagi R, and Nawata H.
  Insulin-like grouth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor.
  J. Biol. Chem. 282, 7329-7338 (2007) doi: 10.1074/jbc.M610447200

• Yamagata K, Yoshimochi K, Daitoku H, Hirota K, and Fukamizu A.
  Bile acid represses the PGC-1 promoter activity via SHP-dependent manner.
  Int. J. Mol. Med. 19, 751-756 (2007) doi: 10.3892/ijmm.19.5.751

• Asada S, Daitoku H, Matsuzaki H, Saito T, Sudo T, Mukai H, Iwashita S, Kako K, Kishi T, Kasuya Y, and Fukamizu A.
  Mitogen-activated protein kinase, Erk and p38, phosphorylate and regulate Foxo1.
  Cell. Signal. 3, 519-527 (2007) doi:10.1016/j.cellsig.2006.08.015

2006

• Nakae J, Cao Y, Daitoku H, Fukamizu A, Ogawa W, Yano Y, and Hayashi Y.
  The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity.
  J. Clin. Invest. 116, 2473-2483 (2006) doi: 10.1172/JCI25518

• Marchetti V, Menghini R, Rizza S, Vivanti A, Feccia T, Lauro D, Fukamizu A, Lauro R, and Federici M.
  Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differntiation via Akt/FoxO singaling.
  Diabetes 55, 2231-2237 (2006) doi: 10.2337/db06-0369

• Inoue Y, Itoh Y, Abe K, Okamoto T, Daitoku H, Fukamizu A, Onozaki K, and Hayashi H.
  Smad3 is acetylated by p300/CBP to regulate its transactivation activity
  Oncogene 26, 500-508 (2006) doi:10.1038/sj.onc.1209826

• Aoyama H, Daitoku H, and Fukamizu A.
  Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice
  Int. J. Mol. Med. 18, 433-439 (2006) doi: 10.3892/ijmm.18.3.433

• Hashimoto T, Kihara M, Ishida J, Imai N, Yoshida S, Toya Y, Fukamizu A, Kitamura H. and Umemura S.
  Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells
  Arterioscler. Thromb. Vasc. Biol. 26, 1267-1272 (2006) doi: 10.1161/01.ATV.0000218841.39828.91

• Utsunomiya R, Suto K, Balasundaresan D, Fukamizu A, Kumar PK, and Mizuno H.
  Structure of an RNA duplex r(GGCG(Br)UGCGCU)(2) with terminal and internal tandem G.U base pairs
  Acta Crystallogr. D Biol. Crystallogr. 62, 331-338 (2006) doi:10.1107/S0907444905043210

• Aratani S, Oishi T, Fujita H, Nakazawa M, Fujii R, Imamoto N, Yoneda Y, Fukamizu A, and Nakajima T.
  The nuclear import of RNA helicase A is mediated by importin-alpha3
  Biochem. Biophys. Res. Commun. 340, 125-133 (2006) doi:10.1016/j.bbrc.2005.11.161

• Hatta M, Yoshimura Y, Deyama Y, Fukamizu A, and Suzuki K.
  Molecular characterization of the zinc finger transcription factor, Osterix
  Int. J. Mol. Med. 17, 425-430 (2006) doi: 10.3892/ijmm.17.3.425

2005

• Nakahara M, Furuya N, Takagi K, Sugaya T, Hirota K, Fukamizu A, Kanda T, Fujii H, and Sato R.
  Ileal bile acid-binding protein functionally associated with the farnesoid X receptor or Ileal bile acid transporter regulates bile acid activity in the small intestine
  J. Biol. Chem. 280, 42283-42289 (2005)

• Hashimoto T, Kihara M, Sato K, Matsushita K, Tanimoto K, Toya Y, Fukamizu A, and Umemura S.
  Expression of cyclooxygenase-2 in the juxtaglomerular apparatus of angiotensinogen gene-knockout mice
  Nephron Physiol. 102, 1-8 (2005)

• Kato H, Ishida J, Imagawa S, Saito T, Suzuki N, Matsuoka T, Sugaya T, Tanimoto K, Yokoo T, Ohneda O, Sugiyama F, Yagami K, Fujita T, Yamamoto M, Nangaku M, and Fukamizu A.
  Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a receptor
  FASEB J. 19, 2023-2025 (2005)

• Suzuki N, Fujimoto Z, Morita T, Fukamizu A, and Mizuno H.
  pH-dependent structual changes at Ca2+-binding sites of coagulation factor IX-binding protein
  J. Mol. Biol. 353, 80-87 (2005)

• Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, Yang P, Sarao R, Wada T, Leong-Poi H, Crackower M, Fukamizu A, Hui CC, Hein L, Uhlig S, Slutsky AS, Jiang C, and Penninger JM.
  Angiotensin-converting enzyme 2 protects from severe acute lung failure
  Nature 436, 112-116 (2005)

• Nakanishi, M., Saito, Y., Kishimoto, I., Harada, M., Kuwahara, K., Takahashi, N., Kawakami, R., Nakagawa, Y., Tanimoto, K., Yasuno, S., Usami, S., Li, Y., Adachi, Y., Fukamizu, A., Garbers, D.L., Nakao, K.
  Role of natriuretic peptide receptor guanylyl cyclase-A in myocardial infarction evaluated using genetically engineered mice
  Hypertension 46, 441-447 (2005)

• Matsuzaki, H., Daitoku, H., Hatta, M., Aoyama, H., Yoshimochi, K., and Fukamizu, A.
  Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation
  Proc. Natl. Acad. Sci. USA 102, 11278-11283 (2005)

• Kunori, Y., Muroga, Y., Iidaka, M, Mitsuhashi, H., Kamimura, T., and Fukamizu, A.
  Species differences in angiotensin II generation and degradation by mast cell chymases
  J. Recept. Signal Transduct. Res. 25, 35-44 (2005)

• Tanimoto K, Shimotsuma M, Matsuzaki H, Omori A, Bungert J, Engel JD, and Fukamizu A.
  Genomic imprinting recapitulated in the human b-globin locus
  Proc. Natl. Acad. Sci. USA 102, 10250-10255 (2005)

• Tsuchimochi K, Yagishita N, Yamasaki S, Amano T, Kato Y, Kawahara K, Aratani S, Fujita H, Ji F, Sugiura A, Izumi T, Sugamiya A, Maruyama I, Fukamizu A, Komiya S, Nishioka K, and Nakajima, T.
  Identification of a crucial site for Synoviolin expression
  Mol. Cell. Biol. 25, 7344-7356 (2005)

• Kouyama R, Suganami T, Nishida J, Tanaka M, Toyoda T, Kiso M, Chiwata T, Miyamoto Y, Yoshimasa Y, Fukamizu A, Horiuchi M, Hirata Y, and Ogawa Y.
  Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor
  Endocrinology 46, 3481-3489 (2005)

• Hashimoto Y, Ishida J, Yamamoto R, Fujiwara K, Asada S, Kasuya Y, Mochizuki N, and Fukamizu A.
  G protein-coupled APJ receptor signaling induces focal adhesion formation and cell motility
  Int. J. Mol. Med. 16, 787-792 (2005)

• Dateki M, Horii T, Kasuya Y, Mochizuki R, Nagao Y, Ishida J, Sugiyama F, Tanimoto K, Yagami K, Imai H, and Fukamizu A.
  Neurochondrin negatively regulates CaMKII phosphorylation and nervous system specific gene disruption results in epileptic seizure
  J. Biol. Chem. 280, 20503-20508 (2005)

• Omori A, Tanabe O, Engel JD, Fukamizu A, and Tanimoto K.
  Adult stage g-globin silencing is mediated by a promoter direct repeat element
  Mol. Cell. Biol. 25, 3443-3451 (2005)

• Fujita H, Ohshima T, Oishi T, Aratani S, Fujii R, Fukamizu A, and Nakajima T.
  Relevance of nuclear localization and functions of RNA helicase A
  Int. J. Mol. Med. 15, 555-560 (2005)

• Araya N, Hiraga H, Kako K, Arao Y, Kato S, and Fukamizu A.
  Transcriptional down-regulation through nuclear exclusion of EWS methylated by PRMT1
  Biochem. Biophys. Res. Commun. 329, 653-660 (2005)

• Shimizu T, Oishi T, Omori A, Sugiura A, Hirota K, Aoyama H, Saito T, Sugaya T, Kon Y, Engel JD, Fukamizu A, and Tanimoto K.
  Identification of cis-regulatory sequences in the human angiotensinogen gene using transgene coplacement and site-specific recombination
  Mol. Cell. Biol. 25, 2938-2945 (2005)

• Takimoto-Ohnishi E, Saito T, Ishida J, Ohnishi J, Sugiyama F, Yagami K, and Fukamizu A.
  Differential roles of renin and angiotensinogen in the feto-maternal interface to the development of complications of pregnancy
  Mol. Endocrinol. 19, 1361-1372 (2005)

• Yagishita N, Ohneda K, Amano T, Yamasaki S, Sugiura A, Tsuchimochi K, Shin H, Kawahara K, Ohneda O, Ohta T, Tanaka S, Yamamoto M, Maruyama I, Nishioka K, Fukamizu A, and Nakajima T.
  Essential role of synoviolin in embryogenesis
  J. Biol. Chem. 280, 7909-7916 (2005)

• Fujita M, Hayashi I, Yamashina S, Fukamizu A, Itoman M, and Majima M.
  Angiotensin type 1a receptor signaling-dependent induction of vascular endothelial growth factor in stroma is relevant to tumor-associated angiogenesis and tumor growth
  Carcinogenesis 26, 271-279 (2005)

• Hirota K, Aoyama H, and Fukamizu A.
  Mutation analysis of HNF-4 binding sites in the human glucose-6-phosphatase promoter
  Int. J. Mol. Med. 15, 487-490 (2005)

2004

• Asada S, Takanami-Ohnishi Y, Zhou J, Hama H, Fukamizu A, Kimura S, Goto K, and Kasuya Y.
  Cytodifferentiation enhances Erk activation induced by endothelin-1 in primary cultured astrocytes
  J. Cardiovasc. Pharmacol. 44, S307-S312 (2004)

• Kako K, Takehara A, Arai H, Onodera T, Takahashi Y, Hanagata H, Ogra Y, Takagi, H, Kodama H, Suzuki KT, Munekata E, and Fukamizu A.
  A selective requirement for copper-dependent activation of cytochrome c oxidase by Cox17p
  Biochem. Biophys. Res. Commun. 324, 1379-1385 (2004)

• Kunori Y, Hase N, Kawamura T, Sato H, Kasai H, Muroga Y, Kamimura T, and Fukamizu A.
  Generation and characterization of new monoclonal antibodies against human chymase
  Hybridoma and Hybridomics 23, 237-243 (2004)

• Kamijo A, Sugaya T, Hikawa A, Okada M, Okumura F, Yamanouchi M, Honda A, Okabe M, Fujino T, Hirata Y, Omata M, Kaneko R, Fujii H, Fukamizu A, and Kimura K.
  Urinary excretion of fatty acid binding protein reflects stress overload on the proximal tubules
  Am. J. Pathol. 165, 1243-1255 (2004)

• Mochizuki-Sakisaka R, Dateki M, Ishizuka Y, Yanai K, Matsuda Y, Koga Y, and Fukamizu A.
  Structural organization of the mouse neurochondrin gene
  Int. J. Mol. Med. 14, 361-366 (2004)

• Sato K, Kihara M, Hashimoto T, Matsushita K, Koide Y, Tamura K, Hirawa N, Toya Y, Fukamizu A, and Umemura S.
  Alterations in renal endothelial nitric oxide synthase expression by salt diet in Angiotensin type-1a receptor gene knockout mice
  J. Am. Soc. Nephrol. 15, 1756-1763 (2004)

• Daitoku H, Hatta M, Matsuzaki H, Aratani S, Ohshima T, Miyagishi M, Nakajima T, and Fukamizu A.
  Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
  Proc. Natl. Acad. Sci. USA 101, 10042-10047 (2004)

• Zou Y, Akazawa H, Qin Y, Sano M, Takano H, Minamino T, Makita N, Iwanaga K, Zhu W, Kudoh S, Toko H, Tamura K, Kihara M, Nagai T, Fukamizu A, Umemura S, Iiri T, Fujita T, and Komuro I.
  Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
  Nat. Cell Biol. 6, 499-506 (2004)

• Ishida J, Hashimoto T, Hashimoto Y, Nishiwaki S, Iguchi T, Harada S, Sugaya T, Matsuzaki H, Yamamoto R, Shiota N, Okunishi H, Kihara M, Umemura S, Sugiyama F, Yagami KI, Kasuya Y, Mochizuki N, and Fukamizu A.
  Regulatory roles for APJ, a seven-transmembrane receptor related to AT1, in blood pressure in vivo
  J. Biol. Chem. 279, 26274-26279 (2004)

• Yamagata K, Daitoku H, Shimamoto Y, Matsuzaki H, Hirota K, Ishida J, and Fukamizu A.
  Bile acids regulate gluconeogenic gene expression via SHP-mediated repression of HNF-4 and Foxo1
  J. Biol. Chem. 279, 23158-23165 (2004)

• Ide T, Shimano H, Yahagi N, Matsuzaka T, Nakakuki M, Yamamoto T, Nakagawa Y, Takahashi A, Suzuki H, Sone H, Toyoshima H, Fukamizu A, and Yamada N.
  SREBPs suppress IRS-2-mediated insulin signalling in the liver
  Nat. Cell Biol. 6, 351-357 (2004)

• Ieda M, Fukuda K, Hisaka Y, Kimura K, Kawaguchi H, Fujita J, Shimoda K, Takeshita E, Okano H, Kurihara Y, Kurihara H, Ishida J, Fukamizu A, Federoff HJ and Ogawa S.
  Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression
  J. Clin. Invest. 113, 876-884 (2004)

• Shimamoto Y, Ishida J, Yamagata K, Saito T, Kato H, Matsuoka T, Hirota K, Daitoku H, Nangaku M, Yamagata K, Fujii H, Takeda J, and Fukamizu A.
  Inhibitory effect of the small heterodimer partner on hepatocyte nuclear factor-4 mediated bile acid-induced repression of the human angiotensinogen gene
  J. Biol. Chem. 279, 7770-7776 (2004)

• Shimamoto Y, Hirota K, and Fukamizu A.
  Effect of peroxisome proliferator-activated receptor alpha on human angiotensinogen promoter
  Int. J. Mol. Med. 13, 729-733 (2004)

• Dateki M, Mochizuki R, Yanai K, and Fukamizu A.
  Identification of the mouse neurochondrin promoter region and the responsible region for cell type specific gene regulation
  Neurosci. Lett. 356, 107-110 (2004)

• Date S, Nibu Y, Yanai K, Hirata J, Yagami K, and Fukamizu A.
  Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene
  Int. J. Mol. Med. 13, 637-642 (2004)

• Saito T, Ishida J, Takimoto-Ohnishi E, Takamine S, Shimizu T, Sugaya T, Kato H, Matsuoka T, Nangaku M, Kon Y, Sugiyama F, Yagami K, and Fukamizu A.
  An essential role for angiotensin II type 1a receptor in pregnancy-associated hypertension with intrauterine growth retardation
  FASEB J. 18, 388-390 (2004)

2003

• Araya, N., Hirota, K., Shimamoto, Y., Miyagishi, M., Yoshida, E., Ishida, J.,
  Kaneko, S., Kaneko, M., Nakajima, T., and Fukamizu, A.
  Cooperative interaction of EWS with CREB-binding protein selective activates hepatocyte nuclear factor 4-mediated transcription
  J. Biol. Chem. 278, 5427-5432 (2003)

• Daitoku, H., Yamagata, K., Matsuzaki, H., Hatta, M., and Fukamizu, A.
  Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription facter FKHR
  Diabetes 52, 642-649 (2003)

• Hirota, K., Daitoku, H., Matsuzaki, H., Araya, N., Yamagata, K., Asada, S., Sugaya, T., and Fukamizu, A.
  Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor
  J. Biol. Chem. 278, 13056-13060 (2003)

• Fujita, H., Fujii, R., Aratani, S., Amano, T., Fukamizu, A., and Nakajima, T.
  Antithetic effects of MBD2a on gene regulation
  Mol. Cell. Biol. 23, 2645-2657 (2003)

• Saito, T., Oishi, T., Yanai, K., Shimamoto, Y., and Fukamizu, A.
  Cloning and chracterization of a novel splicing isoform of USF1
  Int. J. Mol. Med. 12, 161-167 (2003)

• Aratani, S., Fujii, R., Fujita, H., Fukamizu, A., and Nakajima, T.
  Aromatic residuces are required for RNA helicase A medical transactivation
  Int. J. Mol. Med. 12, 175-180 (2003)

• Fukuoka, M., Daitoku, H., Hatta, M., Matsuzaki, H., Umemura, S., and Fukamizu, A.
  Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation
  Int. J. Mol. Med. 12, 503-508 (2003)

• Matsuzaki, H., Daitoku, H., Hatta, M., Tanaka, K., and Fukamizu, A.
  Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation
  Proc. Natl. Acad. Sci. USA 100, 11285-11290 (2003)

• Amano, T., Yamasaki, S., Yagishita, N., Tsuchimochi, K., Shin, H., Kawahara, K., Aratani, S., Fujita, H., Zhang, L., Ikeda, R., Fujii, R., Miura, N., Komiya, S., Nishioka, K., Maruyama, I., Fukamizu, A., and Nakajima, T.
  Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy
  Genes Dev. 17, 2436-2449 (2003)

• Mochizuki, R., Dateki, M., Yanai, K., Ishizuka, Y., Amizuka, N., Kawashima, H.,Koga, Y., Ozawa, H., and Fukamizu, A.
  Targeted disruption of the neurochondrin/norbin gene results in embryonic lethality
  Biochem. Biophys. Res. Commun. 310, 1219-1226 (2003)

• Tanimoto, K., Sugiura, A., Omori, A., Felsenfeld, G., Engel, J.D., and Fukamizu, A.
  Human beta-globin locus control region HS5 contains CTCF- and developmental stage-dependent enhancer-blocking activity in erythroid cells
  Mol. Cell. Biol. 23, 8946-52 (2003)

• Kako, K., Takahashi,Y., Inada, Y., Hisano, S., Munekata, E., and Fukamizu, A.
  Histochemical analysis of copper chaperone proteins -Cox17p, Sco1p and Sco2p- in different regions of the mouse brain.
  Biomed. Res. Trace Elements 14, 284-286 (2003)

• Nishinokubi, I., Shimoda, M., Kako, K., Sakai, T., Fukamizu, A., and Ishida, N.
  Highly conserved Drosophila ananassae timeless gene functions as a clock component in Drosophila melanogaster.
  Gene 307, 183-190 (2003)

2002

• Hatta, M., Daitoku, H., Matsuzaki, H., Deyama, Y., Yoshimura, Y., Suzuki, K., Matsumoto, A., and Fukamizu, A.
  Regulation of alkaline phosphatase promoter activity by forkhead transcription factor FKHR
  Int. J. Mol. Med. 9, 147-152 (2002)

• Kawabata, H., Kawahara, K., Kanekura, T., Araya, N., Daitoku, H., Hatta, M., Miura,N., Fukamizu, A., Kanzaki, T., Maruyama, I. and Nakajima, T.
  Possible role of transcriptional coactivator P/CAF and nuclear acetylation in calcium-induced keratinocyte differentiation
  J. Biol. Chem. 277, 8099-8105 (2002)

• Saitoh, M., Takayanagi, R., Goto, K., Fukamizu, A., Tomura, A., Yanase, T. and Nawata, H.
  The presence of both the amino- and carboxyl-terminal domains in the AR is essential for the completion of a transcriptionally active form with coactivators and intranuclear compartmentalization common to the steroid hormone receptors: a three-dimensional imaging study
  Mol. Endocrinol. 16, 694-706 (2002)

• Takahashi, Y., Kako K., Arai, H., Ohishi, T., Inada, Y., Takehara, A., Fukamizu, A. and Munekata, E.
  Characterization and idetification of promoter elements in the mouse COX17 gene
  Biochim. Biophys. Acta. 1574, 359-364 (2002)

• Nakazawa, M., Aratani, S., Hatta, M., Araya, N., Daitoku, H., Kawahara, K., Watanabe, S., Nakamura, H., Yoshino, S., Fujii, R., Fujita, H., Fukamizu, A., Nishioka, K. and Nakajima, T.
  TNFa induces acetylation of p53 but attenuates its transcriptional activation in rheumatoid synoviocytes
  Int. J. Mol. Med. 10, 269-275 (2002)

• Kang, N., Walther, T., Tian, XL., Bohlender, J., Fukamizu, A., Ganten, D. and Bader, M.
  Reduced hypertension-induced end-organ damage in mice lacking cardiac and renal angiotensinogen synthesis
  J. Mol. Med. 80, 359-366 (2002)

• Li, Y., kishimoto, I., Saito, Y., Harada, M., Kuwahara, K., Izumi, T., Takahashi, N., Kawakami, R., Tanimoto, K., Nakagawa, Y., Nakanishi, M., Adachi, Y., Garbers, DL., Fukamizu, A. and Nakao, K.
  Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogeneous protective mechanism in the heart
  Circulation 106, 1722-1728 (2002)

• Sano, M., Kuwabara, T., Warashina, M., Fukamizu, A. and Taira, K.
  Novel method for selection of tRNA-driven ribozymes with enhanced stability in mammalian cells
  Antisense Nucl. Drug Dev. 12, 341-352 (2002)

• Kunori,Y., Koizumi, M., Masegi, T., Kasai, H., Kawabata, H., Yamazaki, Y. and Fukamizu, A.
  Rodent α-chymases are elastase-like proteases
  Eur. J. Biochem. 269, 5921-5930 (2002)

2001

• Nakazawa, M., Ishii, H., Nakamura, H., Yoshino, S., Fukamizu, A., Nishioka K., and Nakajima, T.
  NFκB2(p52) promoter activation via Notch signaling pathway in rheumatoid synoviocytes
  Int. J. Mol. Med. 7, 31-35 (2001)

• Ohshima, T., Yoshida, E., Nakajima, T., Yagami, K., and Fukamizu, A.
  Effects of interaction between parvovirus minute virus of mice NS1 and coactivator CBP on NS1- and p53-transactivation
  Int. J. Mol. Med. 7, 49-54 (2001)

• Zhou, J., Moroi, K., Nishiyama, M., Usui, H., Seki, N., Ishida, J., Fukamizu, A.and Kimura, S
  Characterization of RGS5 in regulation of G protein-coupled receptor signaling
  Life Sci. 68, 1457-1469 (2001)

• Fujii, R., Okamoto, M., Aratani, S., Oishi, T., Ohshima, T., Taira, K., Baba, M., Fukamizu, A., and Nakajima, T.
  A role of RNA helicase A in cis-acting transactivation response element-mediated transcriptional regulation of human immunodeficiency virus type 1
  J. Biol. Chem. 276, 5445-5451 (2001)

• Aratani, S., Fujii, R., Oishi, T., Fujita, H., Amano, T., Ohshima, T., Hagiwara, M., Fukamizu, A.,and Nakajima, T.
  Dual roles of RNA helicase A in CREB - dependent transcription
  Mol. Cel. Biol. 21, 4460-4469 (2001)

• Hisada, Y., Sugaya, T., Tanaka, S., Suzuki, Y., Ra, C., Kimura, K., and Fukamizu, A.
  An essential role of angiotensin II receptor type 1a in recipient kidney, not in transplanted peripheral blood leukocytes, in progressive immune-mediated renal injury
  Lab. Invest. 81, 1243-1251 (2001)

• Yamamoto, N., Yamamoto Si. S., Inagaki, F., Kawaichi, M., Fukamizu, A., Kishi, N., Matsuno, K., Nakamura, K., Weinmaster, G., Okano, H., and Nakafuku, M.
  Role of deltex-1 as a transcriptional regulator downstream of the notch receptor
  J. Biol. Chem. 276, 45031-45040 (2001)

• Daitoku, H., Ishida, J., Fujiwara, K., Nakajima, T., and Fukamizu, A.
  Dimerization of small GTPase Rab5
  Int. J. Mol. Med. 8, 397-404 (2001)

• Katoh, Y., Ito, K., Yoshida, E., Miyagishi, M., Fukamizu, A., and Yamamoto, M.
  Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
  Genes Cells 6, 857-868 (2001)

• Takanami-Ohnishi, Y., Asada, S., Tsunoda, H., Fukamizu, A., Goto, K., Yoshikawa, H., Kubo, T., Sudo, T., Kimura, S., and Kasuya, Y.
  Possible involvement of p38 mitogen-activated protein kinase in decidual function in parturition
  Biochem. Biophys. Res. Commun. 288, 1155-1161 (2001)

• Massiera, F., Seydoux, J., Geloen, A., Quignard-Boulange, A., Turban, S., Saint-Marc, P., Fukamizu, A., Negrel, R., Ailhaud, G., and Teboul, M.
  Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity
  Endocrinology 142, 5220-5225 (2001)

• Massiera, F., Bloch-Faure, M., Ceiler, D., Murakami, K., Fukamizu, A., Gasc, J.M., Quignard-Boulange, A., Negrel, R., Ailhaud, G., Seydoux, J., Meneton, P., and Teboul, M.
  Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation
  FASEB J. 15, 2727-2729 (2001)

• Nakazawa, M., Ishii, H., Aono, H., Takai, M., Honda, T., Aratani, S., Fukamizu, A., Nakamura, H., Yoshino, S., Kobata, T., Nishioka, K., and Nakajima, T.
  Role of Notch-1 intracelluar domain in activation of rheumatoid synoviocytes
  Arthritis Rheum. 7, 31-35 (2001)

2000

• Miyagishi, M., Hatta, M., Ohshima, T., Ishida, J., Fujii, R., Nakajima, T., and Fukamizu, A.
  Cell type-dependent transactivation or repression of mesoderm-restricted basic helix-loop-helix protein, POD-1/Capsulin
  Mol. Cell. Biochem. 205, 141-147 (2000)

• Mochizuki, R., Ishizuka, Y., Yanai, K., Murakami, K., Koga, Y., and Fukamizu, A.
  Corrigendum to Molecular cloning and expression of human neurochondrin-1 and2.
  Biochim. Biophys. Acta. 1490, 367-368 (2000)

• Usui, H., Nishiyama, M., Moroi, K., Shibasaki, T., Zhou, J., Ishida, J., Fukamizu, A., Haga, T., Sekiya, S., and Kimura, S.
  RGS domain in the amino-terminus of G protein-coupled receptor kinase 2 inhibits Gq-mediated signaling
  Int. J. Mol. Med. 5, 335-340, (2000)

• Yanai, K., Saito, T., Kakinuma, Y., Kon, Y., Hirota, K., Taniguchi-Yanai, K.,
  Nishijo,N.,Shigematsu, Y., Horiguchi, H., Kasuya, Y., Sugiyama, F., Yagami, K., Murakami, K.,and Fukamizu, A.
  Renin-dependent Cardiovascular Functions and Renin-independent Blood Brain Barrier Functions Revealed by Renin-deficient Mice
  J. Biol. Chem. 275, 5-8 (2000)

• Miyagishi, M., Nakajima, T., and Fukamizu, A.
  Molecular characterization of mesoderm-restricted basic helix-loop-helix protein, POD-1/Capsulin
  Int. J. Mol. Med. 5, 27-31 (2000)

• Yang, Q., Yamagata, K., Yamamoto, K., Cao, Y., Miyagawa,J., and Fukamizu, A.,
  Hanafusa, T., and Matsuzawa, Y.
  R127W-HNF-4alpha is a loss of function mutation but not a rare polymorphism and causes type ll diabetes in a Japanese family with MODY1
  Diabetologia 43, 520-524 (2000)

• Ebihara, A., Nasir, U., M., Yoshida, S., Kondou, T., Nakagawa, T., Fukamizu, A., Suzuki, F., Nakamura, Y., and Murakami, K.
  Sialic acid residue of ovine angiotensinogen does not affect the reactivity to human renin
  Biomed. Res. 21, 105-109 (2000)

• Kashiwabara, S., Zhuang, T., Yamagata, K., Noguchi, J., Fukamizu, A., and Baba, T.
  Identification of a novel isoform of poly(A) polymerase, TPAP, specifically present in the cytoplasm of spermatogenic cells
  Dev. Biol. 228, 106-115 (2000)

• Miyagishi, M., Fujii, R., Hatta, M., Yoshida, E., Araya, N., Nagafuchi, A., Ishihara, S., Nakajima, T., and Fukamizu, A.
  Regulation of lef-mediated transcription and p53-dependent pathway by associating b-Catenin with CBP/p300
  J. Biol. Chem. 275, 35170-35175 (2000)

1999

• Ishida, J., Asada, S., Daitoku, H., Fujiwara, K., Kon, Y., Sugaya, T., Murakami, K., Nakajima, T., Kasuya, Y., and Fukamizu, A.
  Expression and characterization of mouse angiotensin II type 1a receptor tagging hemagglutinin epitope in cultured cells
  Int. J. Mol. Med. 3, 263-270 (1999)

• Okuyama, S., Sakagawa, T., Sugiyama, F., Fukamizu, A., and Murakami, K.
  Reduction of depressive-like behavior in mice lacking angiotensinogen
  Neurosci. Lett. 261, 167-170 (1999)

• Walther, T., Voigt, J., Fukamizu, A., Fink, H., and Bader, M.
  Learning and anxiety in angiotensin-deficient mice
  Behavioural Brain Research. 100, 1-4 (1999)

• Hisada, Y., Sugaya,T., Yamanouchi, M., Uchida, H., Fujimura, H., Sakurai, H., Fukamizu, A., and Murakami, K.
  Angiotensin II plays a pathogenic role in immune-mediated renal injury in mice
  J. Clin. Invest. 103, 627-635 (1999)

• Nishijo, N., Takamine, S., Sugiyama, F., Kimoto, K., Taniguchi, K., Horiguchi, H., Ogata, T., Murakami, K., Fukamizu, A., and Yagami, K.
  Vascular remodeling in hypertensive transgenic mice
  Exp. Anim. 48, 203-208 (1999)

• Tanimoto, Y., Tanimoto, K., Sugiyama, F., Horiguchi, H., Murakami, K., Yagami, K., and Fukamizu, A.
  Male sterility in transgenic mice expressing activin bA subunit gene in testis
  Biochem. Biophys. Res. Commun. 259, 699-705 (1999)

• Ishizuka, Y., Mochizuki, R., Yanai, K., Takatsuka, M., Nonomura, T., Niida, S., Horiguchi, H., Maeda, N., and Fukamizu, A.
  Induction of hydroxyapatite resorptive activity in bone marrow cell populations resistant to Bafilomycin A1 by a factor with restricted expression to bone and brain, neurochondrin
  Biochem. Biophs. Acta 1450, 92-98 (1999)

• Nishi, T., Moriguchi, A., Morishita, R., Yamada, K., Nakamura,S., Tomita, N., Kaneda, Y., Fukamizu, A., Mikami, H., Higaki, J., and Toshio Ogihara
  Angiotensinogen gene-activating elements regulate blood pressure in the brain
  Circ. Res. 85, 257-263 (1999)

• Yanai, K., Hirota, K., Taniguchi-yanai, K., Shigematsu, Y., Shimamoto, Y.,
  Saito, T., Chowdhury, S., Takiguchi, M., Arakawa, M., Nibu, Y., Sugiyama, F.,
  Yagami, K., and Fukamizu, A.
  Regulated expression of human angiotensinogen gene by hepatocyte nuclear factor 4 and chicken ovalbumin upstream promoter-transcription factor
  J. Biol. Chem. 274, 34605-34612 (1999)

• Kakinuma, Y., Hama, H., Kasuya, Y., and Fukamizu, A.
  A new role of renin-angiotensin system in the central nervous system Analysis of astrocytes from angiotensiongen-dificient mice, suggesting a crucial role of renin-angiotensin system in blood brain barrier
  Recent Res. Devel. Neurochem. 2, 473-493 (1999)

• Ohshima, T., Nakajima, T., Oishi, T., Imamoto, N., Yoneda, Y., Fukamizu, A., and Yagami, K.
  CRM1 mediates Nuclear Export of Nonstructural Protein 2 from Parvovirus Minute Virus of Mice
  Biochem. Biophys. Res. Commun. 264, 144-150 (1999)

• Kakimuma, Y., Sugiyama, F., Taniguchi, K., Horiguchi, H., Ogata, T., Murakami, K., Yagami, K., and Fukamizu, A.
  Developmental stage-specific involvement of angiotensin in murine nephrogenesis
  Pediatr. Nephrol. 13, 792-799 (1999)

• Kawahara, K., Watanabe, S., Ohshima, T., Soejima, Y., Oishi, T., Aratani, S.,
  Nakata, M., Shibata, M., Inoue, K., Amano, T., Fujii, R., Yanai, K., Hagiwara, M., Fukamizu, A., Maruyama, I., and Nakajima, T.
  Hypernuclear acetylation in atherosclerotic lesions and activated vascular smooth muscle cells
  Biochem. Biophys. Res. Commun. 266, 417-424 (1999)

• Mochizuki, R., Ishizuka, Y., Yanai, K., Koga, Y., and Fukamizu, A.
  Molecular cloning and expression of human neurochondrin-1 and -2
  Biochim. Biophys. Acta 1446, 397-402 (1999)

1998

• Yoshida E, Tanimoto K, Murakami K, and Fukamizu A.
  Isolation and characterization of 5'-regulatory region of mouse activin _A subunit gene
  Biochem. Mol. Biol. Int. 44, 325-332 (1998)

• Kihara M, Umemura S, Sumida Y, Yokoyama N, Yabana M, Nyui N, Tamura K, Murakami K, Fukamizu A,
  and Ishii M.
  Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice.
  Kindey Int. 53, 548-555 (1998)

• Sumida Y, Umemura S, Tamura K, Kihara M, Kobayashi S, Ishigami T, Yabana M, Nyui N, Ochiai H, Fukamizu A, Miyazaki H, Murakami K, and Ishii M.
  Increased cardiac angiotensin II receptors in angiotensinogen-deficient mice
  Hypertension 31, 45-49 (1998)

• Kihara M, Umemura S, Yabana M, Sumida Y, Nyui N, Tamura K, Kadota T, Kishida R, Murakami K,
  Fukamizu A, and Ishii M.
  Dietary salt loading decreases the expressions of neuronal-type nitric oxide synthase and rennin in the juxtaglomerular apparatus of angiotensinogen gene-knockout mice
  J. Am. Soc. Nephrol. 9, 355-362 (1998)

• Yoshida E, Nakajima T, Murakami K, and Fukamizu A.
  Identification of N-terminal minimal transactivation domain of CBP, p300 and Caenorhabditis elegans homologues
  Gene 208, 307-314 (1998)

• Taniguchi K, Sugiyama F, Kakinuma Y, Uehara S, Nishijho N, Tanimoto K, Murakami K, Fukamizu A, and Yagami K.
  Pathologic characterization of hypotensive C57BL/6J-agt: angiotensinogen-deficient C57BL/6J mice
  Int. J. Mol. Med. 1, 583-587 (1998)

• Umemura S, Kihara M, Sumida Y, Yabana M, Ishigami T, Tamura K, Nyui N, Hibi K, Murakami K,
  Fukamizu A, and Ishii M.
  Endocrinological abnormalities in angiotensinogen-gene knockout mice: studies of hormonal responses to dietary salt loading
  J. Hypertens. 16, 285-289 (1998)

• Maki S, Miyauchi T, Sakai S, Kobayashi T, Maeda S, Takata Y, Sugiyama F, Fukamizu A, Murakami K,
  Goto K, and Sugishita Y.
  Endothelin-1 expression in hearts of transgenic hypertensive mice overexpressing angiotensin II
  J. Cardiovasc. Pharmacol. 31 (Suppl. 1), S412-S416 (1998)

• Kihara M, Umemura S, Sugaya T, Toya Y, Yabana M, Kobayashi S, Tamura K, Kadota T, Kishida R, Murakami K, Fukamizu A, and Ishii M.
  Expression of neuronal type nitric oxide synthase and renin in the juxtaglomerular apparatus of angiotensin type-1a receptor gene-knockout mice
  Kidney Int. 53, 1585-1593 (1998)

• Kai T, Kino H, Sugimura K, Shimada S, Kurooka A, Akamatsu K, Takenaka T, Fukamizu A, Murakami K, Ishikawa K, and Katori R.
  Significant role of the increase in renin-angiotensin system in cardiac hypertrophy and renal glomerular sclerosis in double transgenic tsukuba hypertensive mice carrying both human renin and angiotensinogen genes
  Clin. Exp. Hypertens. 20, 439-449 (1998)

• Shiota N, Fukamizu A, Okunishi H, Takai S, Murakami K, and Miyazaki M.
  Cloning of the gene and cDNA for hamster chymase 2, and expression of chymase 1, chymase 2 and angiotensin-converting enzyme in the terminal stage of cardiomyopathic hearts
  Biochem. J. 333, 417-424 (1998)

• Tamura K, Umemura S, Nyui N, Yabana M, Toya Y, Fukamizu A, Murakami K, and Ishii M.
  Possible role of c-Jun in transcription of the mouse renin gene
  Kidney Int. 54, 382-393 (1998)

• Tamura K, Umemura S, Sumida Y, Nyui N, Kobayashi S, Ishigami T, Kihara M, Sugaya T, Fukamizu A, Miyazaki H, Murakami K, and Ishii M.
  Effect of genetic deficiency of angiotensinogen on the renin-angiotensin system
  Hypertension 32, 223-227 (1998)

• Kakinuma Y, Hama H, Sugiyama F, Yagami K, Goto K, Murakami K, and Fukamizu A.
  Impaired blood-brain barrier function in angiotensinogen-deficient mice
  Nature Med. 4, 1078-1080 (1998)

• Ishida J, Sugiyama F, Tanimoto K, Taniguchi K, Syouji M, Takimoto E, Horiguchi H, Murakami K, Yagami K, and Fukamizu A.
  Rescue of Angiotensinogen-Knockout Mice
  Biochem. Biophys. Res. Commun. 252, 610-616 (1998)

• Nishijo N, Sugiyama F, Kimoto K, Taniguchi K, Murakami K, Suzuki S, Fukamizu A, and Yagami K.
  Salt-sensitive aortic aneurysm and rupture in hypertensive transgenic mice that overproduce angiotensin II
  Lab. Invest. 78, 1059-1066 (1998)

• Ohshima T, Iwama M, Ueno Y, Sugiyama F, Nakajima T, Fukamizu A, and Yagami K..
  Induction of apoptosis in vitro and in vivo by H-1 parvovirus infection
  J. Gen. Virol. 79, 3067-3071 (1998)

1997

• Bohlender J, Fukamizu A, Lippoldt A, Nomura T, Dietz R, Mard J, Murakami K, Luft FC, and Ganten D.
  High renin hypertension in transgenic rats
  Hypertension 29, Pt2, 428-434 (1997)

• Kihara M, Umemura S, Kadota T, Yabana M, Ogawa N, Nyui N, Tamura K, Fukamizu A, Murakami K, and Ishii M.
  The neuronal isoform of constitutive nitric oxide synthase is upregulated in the macula densa of angiotensinogen gene-knockout mice.
  Lab. Invest. 76, 285-294 (1997)

• Tamura K, Umemura S, Nyui N, Yamaguchi S, Ishigami T, Hibi K, Yabana M, Kihara M, Fukamizu A, Murakami K, and Ishii M.
  A novel proximal element mediates the regulation of mouse Ren-1C promoter by retinoblastoma protein in cultured cells.
  J. Biol. Chem. 272, 16845-16851 (1997)

• Nyui N, Tamura K, Mizuno K, Ishigami T, Hibi K, Yabana M, Kihara M, Fukamizu A, Ochiai H, Umemura S, Murakami K, Ohno S, and Ishii M.
  Strecth-induced map kinase activation in cardiomyocytes of angiotensinogen-deficient mice
  Biochem. Biophys. Res. Commun. 235, 36-41 (1997)

• Shiota N, Fukamizu A, Takai S, Okunishi H, Murakami K, and Miyazaki M.
  Activation of angiotensin II-forming chymase in the cardiomyopathic hamster heart
  J. Hypertens. 15, 431-440 (1997)

• Sugiyama F, Haraoka S, Watanabe T, Shiota N, Taniguchi K, Ueno Y, Tanimoto K, Murakami K,
  Fukamizu A, and Yagami K.
  Acceleration of atherosclerotic lesions in transgenic mice with hypertension by the activated renin-angiotensin system
  Lab. Invest. 76, 835-842 (1997)

• Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, Kawakami T, Arioka K, Sato H, Uchiyama Y, Masushige S, Fukamizu A, Matsumoto T, and Kato S.
  Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning.
  Nat. Genet. 16, 391-396 (1997)

• Yanai K, Matsuyama S, Murakami K, and Fukamizu A.
  Differential action of AGCF2 upon cell type-dependent expression of human angiotensinogen gene
  FEBS Lett. 412, 285-289 (1997)

• Yanai K, Murakami K, and Fukamizu A.
  ATF-like element contributes to hepatic activation of human angiotensinogen promoter.
  Biochem. Biophys. Res. Commun. 237, 158-162 (1997)

• Kakinuma Y, Hama H, Sugiyama F, Goto K, Murakami K, and Fukamizu A.
  Anti-apoptotic action of angiotensin fragments to neuronal cells from angiotensinogen knock-out mice.
  Neurosci. Lett. 232, 167-170 (1997)

• Sugiyama F, Tanimoto Y, Kato H, Nomura T, Taniguchi K, Tanimoto K, Murakami K, Fukamizu A, and Yagami K.
  Speedy backcrossing through in vitro fertilization, using pre-pubertal superovulation and neonatal death dependent on genetic background in angiotensinogen-deficient mice
  Lab. Anim. Sci. 47, 545-548 (1997)

• Yanai K, Saito T, Hirota K, Kobayashi H, Murakami K, and Fukamizu A.
  Molecular variation of the human angiotensinogen core promoter element located between the TATA box and transcription initiation site affects its transcriptional activity.
  J. Biol. Chem. 272, 30558-30562 (1997)

• Yoshida E, Aratani S, Itou H, Miyagishi M, Takiguchi M, Osumi T, Murakami K, and Fukamizu A.
  Functional association between CBP and HNF4 in trans-activation
  Biochem. Biophys. Res. Commun. 241, 664-669 (1997)

1996

• Yanai K, Nibu Y, Murakami K, and Fukamizu A.
  A cis-acting DNA element located between TATA box and transcription initiation site is critical in response to regulatory sequences in human angiotensinogen gene.
  J. Biol. Chem. 271, 15981-15986 (1996)

• Nakajima T, Fukamizu A, Takahashi J, Gage F.H., Fisher T, Blenis J, and Montminy M.R.
  The signal-dependent coactivator CBP is a nuclear target for pp90RSK.
  Cell 86, 465-474 (1996)

• Takimoto E, Ishida J, Sugiyama F, Horiguchi H, Murakami K, and Fukamizu A.
  Hypertension indcued in pregnant mice by placental renin and maternal angiotensinogen
  Science 274, 995-998 (1996)

• Tanimoto K, Yoshida E, Mita S, Nibu Y, Murakami K, and Fukamizu A.
  Human activin bA gene: identification of novel 5' exon, functional promoter, and enhancers
  J. Biol. Chem. 271, 32760-32769 (1996)

• Nagata M, Tanimoto K, Fukamizu A, Kon Y, Sugiyama F, Yagami K, Murakami K, and Watanabe T.
  Nephrogenesis and renovascular development in angiotensinogen-deficient mice
  Lab. Invest. 75, 745-753 (1996)

• Kon Y, Endoh D, Fukamizu A, Murakami K, Yamashita T, and Watanabe T.
  Detection of coagulating gland renin by hybridohistochemistry
  Anat. Histol. Embryol. 25, 289-294 (1996)

1995

• Sagara M, Sugiyama F, Horiguchi H, Kamma H, Ogata T, Yagami K, Murakami K, and Fukamizu A.
  Activation of the nuclear oncogenes N-myc and c-jun in cartinoid tumors of transgenic mice carrying the human adenovirus type 12 E1 region gene
  DNA Cell Biol. 14, 95-101 (1995)

• Sugiyama F, Sagara M, Matsuda Y, Horiguchi H, Kamma H, Ogata T, Hatae T, Yagami K, Murakami K,
  and Fukamizu A.
  Heritable formation of neuroectodermal tumor in transgenic mice carrying the combined E1 region gene of human adenovirus type 12 with the deregulated human renin promoter
  J. Cell. Biochem. 57, 691-700 (1995)

• Shimada S, Yanai K, Takahashi S, Murakami K, and Fukamizu A.
  Identification of two distinct Sp1- and RBF-1-like nuclear factors that bind to the upstream region of the human angiotensinogen promoter.
  Endocrine 3, 543-547 (1995)

• Sugaya T, Nishimatsu S, Tanimoto K, Takimoto E, Yamagishi T, Imamura K, Goto S, Imaizumi K, Hisada Y, Otsuka A, Uchida H, Sugiura M, Fukuta K, Fukamizu A, and Murakami K.
  Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia
  J. Biol. Chem. 270, 18719-18722 (1995)

• Tomita N, Morishita R, Higaki J, Aoki M, Nakamura Y, Mikami H, Fukamizu A, Murakami K, Kaneda Y,
  and Ogihara T.
  Transient decrease in high blood pressure by in vivo transfer of antisense oligodeoxynucleotides against rat angiotensinogen
  Hypertension 26, 131-136 (1995)

• Goto Y, Sugiyama F, Tanimoto K, Ishida J, Syoji M, Takahashi A, Sugiyama Y, Murakami K, Fukamizu A,
  and Yagami K.
  Evaluation of coculture aggregation with TT2 cells for production of germline chimera
  Lab. Anim. Sci. 45, 601-603 (1995)

• Uehara S, Mino N, Tsuchida M, Nishikibe M, Fukamizu A, Murakami K, and Ikemoto F.
  Development of Polyuria in tsukuba hypertensive mice carrying human renin and angiotensinogen genes
  Clin. Exp. Pharmacol. Physiol. 22, S12-S14 (1995)

1994

• Fukamizu A, Uehara S, Hatae T, Tamura K, Watanabe K, Sugiyama F, and Murakami K.
  Species-specific expression of the hepatic renin gene
  J. Vet. Med. Sci. 56, 109-114 (1994)

• Fukamizu A, Sagara M, Sugiyama F, Yagami K, and Murakami K.
  Tissue-specific trans-activation of renin gene by targeted expression of adenovirus E1A in transgenic mice
  Biochem. Biophys. Res. Commun. 199, 183-190 (1994)

• Tamura K, Umemura S, Iwamoto T, Yamaguchi S, Kobayashi S, Takeda K, Tokita Y, Takagi N, Murakami K, Fukamizu A, and Ishii M.
  Moelcular mechnism of adipogenic activation of the angiotensinogen gene
  Hypertension 23, 364-368 (1994)

• Tanimoto K, Murakami K, and Fukamizu A.
  Combinatorial action of cAMP and phorbol ester on synergistic expression of the human activin A gene
  Exp. Cell. Res. 211, 408-414 (1994)

• Tamura K, Umemura S, Ishii M, Tanimoto K, Murakami K, and Fukamizu A.
  Molecular mechanism of transcriptional activation of angiotensinogen gene by proximal promoter
  J. Clin. Invest. 93, 1370-1379 (1994)

• Hatae T, Takimoto E, Murakami K, and Fukamizu A.
  Comparative studies on species-specific reactivity between renin and angiotensinogen
  Mol. Cell. Biochem. 131, 43-47 (1994)

• Tomura D, Obika K, Fukamizu A, and Shoun H.
  Nitric oxide reductase cytochrome P-450 gene, CYP55, of the fungus Fusarium oxysporum containing a potential binding-site for FNR, the transcription factor involved in the regulation of anaerobic growth of Escherichia coli
  J. Biochem. 116, 88-94 (1994)

• Nagase M, Suzuki F, Fukamizu A, Takeda N, Takeuchi K, Murakami K, and Nakamura Y.
  Sequencing and expression of sheep angiotensinogen cDNA
  Biosci. Biotechnol. Biochem. 58, 1884-1885 (1994)

• Fukamizu A and Murakami K.
  Transgenic hypertensive animals carrying genes for the components of the renin-angiotensin system
  Jpn. Heart J. 35, 492-493 (1994)

• Nibu Y, Takahashi T, Tanimoto K, Murakami K, and Fukamizu A.
  Identification of cell type-dependent enhancer core element located in the 3'-downstream region of the human angiotensinogen gene
  J. Biol. Chem. 269, 28598-28605 (1994)

• Nibu Y, Tanimoto K, Takahashi S, Ono H, Murakami K, and Fukamizu A.
  A cell type-dependent enhancer core element is located in exon 5 of the human angiotensinogen gene.
  Biochem. Biophys. Res. Commun. 205, 1102-1108 (1994)

• Fukamizu A, Sagara M, Sugiyama F, Horiguchi H, Kamma H, Hatae T, Ogata T, Yagami K, and Murakami K.
  Neuroectodermal tumors expressing c-, L-, and N-myc in transgenic mice that carry the E1A/E1B gene of human adenovirus type 12
  J. Biol. Chem. 269, 31252-31258 (1994)

• Tanimoto K, Sugiyama F, Goto Y, Ishida J, Takimoto E, Yagami K, Fukamizu A, and Murakami K.
  Angiotensinogen-deficient mice with hypotension
  J. Biol. Chem. 269, 31334-31337 (1994)

• Tamura K, Umemura S, Yamaguchi S, Iwamoto T, Kobayashi S, Fukamizu A, Murakami K, and Ishii M.
  Mechanism of cAMP regulation of renin gene transcription by proximal promoter
  J. Clin. Invest. 94, 1959-1967 (1994)

• Fukamizu A, Watanabe M, Inoue Y, Kon Y, Shimada S, Shiota N, Sugiyama F, and Murakami K.
  Cortical expression of the human angiotensinogen gene in the kidney of transgenic mice
  Kidney Int. 46, 1533-1535 (1994)