Modified amino acid database (MAADB) is a database for chemically-modified free- or protein-incorporated amino acids, and is globally opened by ‘Crosstalk between transcriptional control and energy pathways, mediated by hub metabolites’ supported by Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015, JAPAN.
In the transcriptional control system, hub metabolites (intracellular metabolic products), such as ATP, acetyl-CoA, and S-adenosylmethionine (SAM) are assumed to regulate functions of histone and the transcription factors through post-translational modifications (for example, phosphorylation, acetylation, and methylation) of their amino acid side chains as functional group-donors.
We fluorescent-labeled amino acids and their modified ones at the alpha-amino group, and analyzed their chemical characters by using Ultra-performance liquid chromatography (UPLC) and mass spectrometry.
In this database,
UPLC chromatograms
Matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight (MALDI-QIT-TOF) mass spectra
Literatures about them
were deposited.
< Disclaimer>
Although we are doing our best to compile high quality databases, there are no such databases without any errors or mistakes. We make no warranties to those effects and shall not be liable for any damage that may result from errors in the database. You can check the page Known Errors of Mistakes in MAADB. When you find new errors or mistakes, please inform us (Dr. Koichiro Kako) by email (